| GABA and glycine in synaptic vesicles: storage and transport characteristics. | |
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MedLine Citation:
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PMID: 1678614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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gamma-Aminobutyric acid (GABA) and glycine are major inhibitory neurotransmitters that are released from nerve terminals by exocytosis via synaptic vesicles. Here we report that synaptic vesicles immunoisolated from rat cerebral cortex contain high amounts of GABA in addition to glutamate. Synaptic vesicles from the rat medulla oblongata also contain glycine and exhibit a higher GABA and a lower glutamate concentration than cortical vesicles. No other amino acids were detected. In addition, the uptake activities of synaptic vesicles for GABA and glycine were compared. Both were very similar with respect to substrate affinity and specificity, bioenergetic properties, and regional distribution. We conclude that GABA, glycine, and glutamate are the only major amino acid neurotransmitters stored in synaptic vesicles and that GABA and glycine are transported by similar, if not identical, transporters. |
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Authors:
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P M Burger; J Hell; E Mehl; C Krasel; F Lottspeich; R Jahn |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuron Volume: 7 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-09-20 Completed Date: 1991-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 287-93 Citation Subset: IM |
Affiliation:
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Department of Neurochemistry, Max-Planck Institute for Psychiatry, Martinsried, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / physiology Cerebral Cortex / chemistry, metabolism, ultrastructure Chromatography, High Pressure Liquid Glutamates / analysis, metabolism, pharmacokinetics Glutamic Acid Glycine / analysis, metabolism*, pharmacokinetics Medulla Oblongata / chemistry, metabolism, ultrastructure Rats Synaptic Vesicles / chemistry, metabolism*, physiology gamma-Aminobutyric Acid / analysis, metabolism*, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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