Document Detail


GABA and homovanillic acid in the plasma of Schizophrenic and bipolar I patients.
MedLine Citation:
PMID:  19701707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have determined the plasma (p) concentration of gamma-aminobutyric acid (GABA) and the dopamine metabolite homovanillic acid (HVA), and the pHVA/pGABA ratio in schizophrenic and bipolar patients. The research was undertaken in a geographic area with an ethnically homogeneous population. The HVA plasma concentrations were significantly elevated in the schizophrenic patients compared to the bipolar patients. The levels of pGABA was significantly lower in the two groups of patients compared to the control group, while the pHVA/pGABA ratio was significantly greater in the both groups of patients compared to the controls. As the levels of pHVA and pGABA are partially under genetic control it is better to compare their concentrations within an homogeneous population. The values of the ratio pHVA/pGABA are compatible with the idea of an abnormal dopamine-GABA interaction in schizophrenic and bipolar patients. The pHVA/pGABA ratio may be a good peripheral marker in psychiatric research.
Authors:
Aurora Arr?e; Ricardo D?vila; Mercedes Zum?rraga; Nieves Basterreche; Miguel A Gonz?lez-Torres; Biotza Goienetxea; Maria I Zamalloa; Juan B Anguiano; Jos? Guim?n
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-22
Journal Detail:
Title:  Neurochemical research     Volume:  35     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-53     Citation Subset:  IM    
Affiliation:
Departamento de Investigaci?n Neuroqu?mica, Hospital de Zamudio, Arteaga Auzoa 45, 48170 Zamudio, Vizcaya, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood
Bipolar Disorder / blood*
Dopamine / metabolism
Female
Homovanillic Acid / blood*
Humans
Male
Middle Aged
Schizophrenia / blood*
gamma-Aminobutyric Acid / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 306-08-1/Homovanillic Acid; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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