| G93A SOD1 alters cell cycle in a cellular model of Amyotrophic Lateral Sclerosis. | |
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MedLine Citation:
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PMID: 20561900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative multifactorial disease characterized, like other diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) or frontotemporal dementia (FTD), by the degeneration of specific neuronal cell populations. Motor neuron loss is distinctive of ALS. However, the causes of onset and progression of motor neuron death are still largely unknown. In about 2% of all cases, mutations in the gene encoding for the Cu/Zn superoxide dismutase (SOD1) are implicated in the disease. Several alterations in the expression or activation of cell cycle proteins have been described in the neurodegenerative diseases and related to cell death. In this work we show that mutant SOD1 can alter cell cycle in a cellular model of ALS. Our findings suggest that modifications in the cell cycle progression could be due to an increased interaction between mutant G93A SOD1 and Bcl-2 through the cyclins regulator p27. As previously described in post mitotic neurons, cell cycle alterations could fatally lead to cell death. |
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Authors:
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Emanuela Cova; Andrea Ghiroldi; Stefania Guareschi; Giuliano Mazzini; Stella Gagliardi; Annalisa Davin; Marika Bianchi; Mauro Ceroni; Cristina Cereda |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-31 |
Journal Detail:
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Title: Cellular signalling Volume: 22 ISSN: 1873-3913 ISO Abbreviation: Cell. Signal. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-07-13 Completed Date: 2010-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904683 Medline TA: Cell Signal Country: England |
Other Details:
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Languages: eng Pagination: 1477-84 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory of Experimental Neurobiology, IRCCS, National Neurological Institute C. Mondino, Via Mondino, 2, 27100 Pavia, Italy. emanuela.cova@mondino.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Substitution Amyotrophic Lateral Sclerosis / genetics*, metabolism Cell Cycle* Cell Line Cell Proliferation Cyclin-Dependent Kinase Inhibitor p27 / metabolism Humans Models, Biological Point Mutation Proto-Oncogene Proteins c-bcl-2 / metabolism Stathmin / metabolism Superoxide Dismutase / genetics*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-bcl-2; 0/Stathmin; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27; EC 1.15.1.-/SOD1 G93A protein; EC 1.15.1.-/superoxide dismutase 1; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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