Document Detail


The G894T polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish population.
MedLine Citation:
PMID:  16038712     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The aim of the present study was to investigate the association between premature coronary artery disease and Glu298Asp polymorphism of the endothelial nitric oxide synthase gene. MATERIALS AND METHODS: The eNOS gene polymorphism was analysed in 115 (mean age, 48.1+/-7.9 years) Turkish patients with a diagnosis of premature coronary artery disease and 83 (mean age, 44.6+/-1.4 years) control subjects. The Glu298Asp polymorphism of the endothelial nitric oxide synthase gene was determined by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: The patients group showed an increase in the frequency of the T allele compared to controls (0.456 versus 0.169, p=0.0001). There was a significant association between the TT genotype and premature coronary artery disease [eNOS TT vs. TG and GG; OR=17.000 (CI 95% 3.952-73.125, p=0.0001)]. The eNOS T/G genotypes were not associated with the number of affected vessels (p>0.05). In addition, the family history of premature coronary artery disease, smoking, diabetes, obesity, dyslipidemia and eNOS TT genotype were independent risk factors of coronary artery disease. The patients with eNOS TT genotype had 15 fold risk of coronary artery disease compared with the control group [OR=15.356(CI 95% 3.262-77.289, p=0.001)]. CONCLUSIONS: These results suggest that premature coronary artery disease is associated with the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in our population.
Authors:
Sirri F Cam; Cevad Sekuri; Istemihan Tengiz; Ertugrul Ercan; Abdi Sagcan; Mustafa Akin; Afig Berdeli
Publication Detail:
Type:  Journal Article     Date:  2005-01-16
Journal Detail:
Title:  Thrombosis research     Volume:  116     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-25     Completed Date:  2005-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-92     Citation Subset:  IM    
Affiliation:
Celal Bayar University, Faculty of Medicine, Department of Medical Biology and Genetics, Manisa, Turkey. sirri.cam@bayar.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Amino Acid Substitution
Case-Control Studies
Coronary Artery Disease / enzymology,  genetics*
DNA Mutational Analysis
Gene Frequency
Genotype
Humans
Middle Aged
Nitric Oxide Synthase / genetics*
Nitric Oxide Synthase Type III
Polymorphism, Single Nucleotide*
Risk Factors
Turkey / epidemiology
Chemical
Reg. No./Substance:
EC 1.14.13.39/NOS3 protein, human; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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