Document Detail

G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population.
MedLine Citation:
PMID:  16750224     Owner:  NLM     Status:  MEDLINE    
The functional consequences of the G80A RFC SNP on the expressed reduced folate carrier protein were evaluated by looking at the relationship between intake of folate, plasma folate and cellular stores of the vitamin. The effect on homocysteine was also examined. Homocysteine is a thiol that is known to be inversely associated with folate, and which is considered to be both thrombo- and athrogenic. At high levels, homocysteine may also interfere with nitric oxide mediated vasodilation, cause oxidative injury to, and proliferation of the vascular endothelium, and alter the elastic properties of the vascular wall, contributing to increased blood pressure. Participants (119; 52 male, 67 female) from a NSW retirement village were assessed. Independent of gender, the assimilation of folate from dietary sources into red cells showed a significant association for GG (r=0.399; p=0.022) and GA (r=0.564; p<0.0001) subjects, but not homozygous recessive (AA) individuals (r=0.223; p=0.236). The same genotype based pattern of significance was shown for the association between dietary folate and plasma folate (GG: r=0.524; p=0.002, GA: r=0.408; p=0.002). No genotype-related pattern of significance was shown for the association between dietary folate and homocysteine. When examined by gender, some differences were apparent; one-way ANOVA showed that genotype influenced diastolic blood pressure in males (p=0.019), while only females showed a significant correlation between dietary folate and blood pressure within specific genotypes (Systolic pressure GA: r=-0.372; p=0.025, carriage of A: r=0.-0.357; p=0.011. Diastolic pressure GA: r=-0.355; p=0.034, carriage of A: r=0.-0.310; p=0.029). The G80A RFC SNP had an impact on the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population.
Lisa Dufficy; Nenad Naumovski; Xiaowei Ng; Barbara Blades; Zoe Yates; Cheryl Travers; Peter Lewis; Jonathon Sturm; Martin Veysey; Paul D Roach; Mark D Lucock
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Publication Detail:
Type:  Journal Article     Date:  2006-05-17
Journal Detail:
Title:  Life sciences     Volume:  79     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-21     Completed Date:  2006-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  957-66     Citation Subset:  IM    
School of Environmental and Life Sciences, University of Newcastle, PO Box 127, Brush Road, Ourimbah NSW 2258, Australia.
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MeSH Terms
Aged, 80 and over
Amino Acid Substitution
Biological Transport / drug effects
Blood Pressure / drug effects*
Erythrocytes / chemistry,  metabolism
Folic Acid / blood,  pharmacokinetics*
Gene Frequency
Homocysteine / metabolism
Membrane Transport Proteins / genetics*,  metabolism*
Models, Biological
New South Wales
Polymorphism, Single Nucleotide
Vitamin B Complex / blood,  pharmacokinetics
Reg. No./Substance:
0/Membrane Transport Proteins; 0/reduced folate carrier; 12001-76-2/Vitamin B Complex; 454-28-4/Homocysteine; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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