| G6PD (AC)n and (CTT)n microsatellites in Mexican Mestizos with common G6PD African variants. | |
MedLine Citation:
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PMID: 17223593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genotyping for the G6PD (AC)n and (CTT)n microsatellites in a sample of 58 Mexican Mestizos with common G6PD African variants was carried out. The second mutation that defines to the variants G6PD A(-202A/376G), G6PD Santamaria(376G/542T) and G6PD A(-376G/968C) very probably occurred on G6PD A(376G) chromosomes with the compound haplotypes, intragenic silent polymorphisms and microsatellites, Pvu-II/Pst-I/Bcl-I/Nla-III/(AC)n/(CTT)n: +/+/-/+/166 bp/195 bp, -/+/-/+/166 bp/201 bp, and -/+/-/+/166 bp/204 bp respectively. The structure of the repeat sequences for the AC-166 bp allele in the 3 variants was (TA)5(AA)1(TA)9(CA)10 whereas the repeat sequences for the CTT-195 bp, CTT-201 bp and CTT-204 bp alleles were (CTT)11(ATT)6, (CTT)7(ATT)12 and (CTT)7(ATT)13 in the first, second and third variants respectively. Genotyping for the G6PD microsatellites can be a useful tool with several applications. |
Authors:
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Gerardo Vaca |
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Publication Detail:
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Type: Journal Article Date: 2007-01-12 |
Journal Detail:
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Title: Blood cells, molecules & diseases Volume: 38 ISSN: 1079-9796 ISO Abbreviation: Blood Cells Mol. Dis. Publication Date: 2007 May-Jun |
Date Detail:
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Created Date: 2007-04-09 Completed Date: 2007-06-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509932 Medline TA: Blood Cells Mol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 238-41 Citation Subset: IM |
Affiliation:
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División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico. gvacap@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group Alleles Glucosephosphate Dehydrogenase / genetics* Glucosephosphate Dehydrogenase Deficiency / genetics Hispanic Americans Humans Microsatellite Repeats* Polymorphism, Genetic |
| Chemical | |
Reg. No./Substance:
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EC 1.1.1.49/Glucosephosphate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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