G6PD (AC)n and (CTT)n microsatellites in Mexican Mestizos with common G6PD African variants. | |
MedLine Citation:
|
PMID: 17223593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Genotyping for the G6PD (AC)n and (CTT)n microsatellites in a sample of 58 Mexican Mestizos with common G6PD African variants was carried out. The second mutation that defines to the variants G6PD A(-202A/376G), G6PD Santamaria(376G/542T) and G6PD A(-376G/968C) very probably occurred on G6PD A(376G) chromosomes with the compound haplotypes, intragenic silent polymorphisms and microsatellites, Pvu-II/Pst-I/Bcl-I/Nla-III/(AC)n/(CTT)n: +/+/-/+/166 bp/195 bp, -/+/-/+/166 bp/201 bp, and -/+/-/+/166 bp/204 bp respectively. The structure of the repeat sequences for the AC-166 bp allele in the 3 variants was (TA)5(AA)1(TA)9(CA)10 whereas the repeat sequences for the CTT-195 bp, CTT-201 bp and CTT-204 bp alleles were (CTT)11(ATT)6, (CTT)7(ATT)12 and (CTT)7(ATT)13 in the first, second and third variants respectively. Genotyping for the G6PD microsatellites can be a useful tool with several applications. |
Authors:
|
Gerardo Vaca |
Related Documents
:
|
25402453 - Loss-of-function mutants and overexpression lines of the arabidopsis cyclin cyca1;2/tar... 18216723 - A novel cyp2a6 allele, cyp2a6*23, impairs enzyme function in vitro and in vivo and decr... 24460333 - Clinical, cytogenetic and cyp1a1 exon-1 gene mutation analysis of beedi workers in vell... |
Publication Detail:
|
Type: Journal Article Date: 2007-01-12 |
Journal Detail:
|
Title: Blood cells, molecules & diseases Volume: 38 ISSN: 1079-9796 ISO Abbreviation: Blood Cells Mol. Dis. Publication Date: 2007 May-Jun |
Date Detail:
|
Created Date: 2007-04-09 Completed Date: 2007-06-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9509932 Medline TA: Blood Cells Mol Dis Country: United States |
Other Details:
|
Languages: eng Pagination: 238-41 Citation Subset: IM |
Affiliation:
|
División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico. gvacap@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
MeSH Terms | |
Descriptor/Qualifier:
|
African Continental Ancestry Group Alleles Glucosephosphate Dehydrogenase / genetics* Glucosephosphate Dehydrogenase Deficiency / genetics Hispanic Americans Humans Microsatellite Repeats* Polymorphism, Genetic |
Chemical | |
Reg. No./Substance:
|
EC 1.1.1.49/Glucosephosphate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Osteonecrosis of the jaws associated with use of risedronate: report of 2 new cases.
Next Document: Ciona intestinalis as a model for cardiac development.