Document Detail

G6PD (AC)n and (CTT)n microsatellites in Mexican Mestizos with common G6PD African variants.
MedLine Citation:
PMID:  17223593     Owner:  NLM     Status:  MEDLINE    
Genotyping for the G6PD (AC)n and (CTT)n microsatellites in a sample of 58 Mexican Mestizos with common G6PD African variants was carried out. The second mutation that defines to the variants G6PD A(-202A/376G), G6PD Santamaria(376G/542T) and G6PD A(-376G/968C) very probably occurred on G6PD A(376G) chromosomes with the compound haplotypes, intragenic silent polymorphisms and microsatellites, Pvu-II/Pst-I/Bcl-I/Nla-III/(AC)n/(CTT)n: +/+/-/+/166 bp/195 bp, -/+/-/+/166 bp/201 bp, and -/+/-/+/166 bp/204 bp respectively. The structure of the repeat sequences for the AC-166 bp allele in the 3 variants was (TA)5(AA)1(TA)9(CA)10 whereas the repeat sequences for the CTT-195 bp, CTT-201 bp and CTT-204 bp alleles were (CTT)11(ATT)6, (CTT)7(ATT)12 and (CTT)7(ATT)13 in the first, second and third variants respectively. Genotyping for the G6PD microsatellites can be a useful tool with several applications.
Gerardo Vaca
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Publication Detail:
Type:  Journal Article     Date:  2007-01-12
Journal Detail:
Title:  Blood cells, molecules & diseases     Volume:  38     ISSN:  1079-9796     ISO Abbreviation:  Blood Cells Mol. Dis.     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-04-09     Completed Date:  2007-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509932     Medline TA:  Blood Cells Mol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-41     Citation Subset:  IM    
División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
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MeSH Terms
African Continental Ancestry Group
Glucosephosphate Dehydrogenase / genetics*
Glucosephosphate Dehydrogenase Deficiency / genetics
Hispanic Americans
Microsatellite Repeats*
Polymorphism, Genetic
Reg. No./Substance:
EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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