Document Detail


G1 cell-cycle control and cancer.
MedLine Citation:
PMID:  15549091     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Before replicating DNA during their reproductive cycle, our cells enter a phase called G1 during which they interpret a flood of signals that influence cell division and cell fate. Mistakes in this process lead to cancer. An increasingly complex and coherent view of G1 signalling networks, which coordinate cell growth, proliferation, stress management and survival, is helping to define the roots of malignancies and shows promise for the development of better cancer therapies.
Authors:
Joan Massagué
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature     Volume:  432     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-19     Completed Date:  2004-12-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  298-306     Citation Subset:  IM    
Affiliation:
Cancer Biology and Genetics Program, and Howard Hughes Medical Institute, Box 116, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York 10021, USA. j-massague@ski.mskcc.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle*
DNA Damage
G1 Phase*
Humans
Neoplasms / genetics,  metabolism*,  pathology*
Signal Transduction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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