Document Detail

G1 and S-phase checkpoints, chromosome instability, and cancer.
MedLine Citation:
PMID:  15187248     Owner:  NLM     Status:  MEDLINE    
Mitogen-dependent progression through the first gap phase (G1) of the mammalian cell-division cycle is precisely regulated so that normal cell division is coordinated with cell growth, while the initiation of DNA synthesis (S phase) is precisely ordered to prevent inappropriate amplification of the DNA that may cause genome instability. To ensure that these fundamental requirements of cell division are met, cells have developed a surveillance mechanism based on an intricate network of protein kinase signaling pathways that lead to several different types of checkpoints. Since these checkpoints are central to the maintenance of the genomic integrity and basic viability of the cells, defects in these pathways may result in either tumorigenesis or apoptosis, depending on the severity and nature of the defects. This review summarizes the genetic and molecular mechanisms of checkpoint activation in the G1/S and S phases of the mammalian cell cycle that monitor DNA damage and replication. The relevance of these mechanisms to the origin of cancer is also discussed.
Hiroshi Nojima
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  280     ISSN:  1064-3745     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-09     Completed Date:  2004-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-49     Citation Subset:  IM    
Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
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MeSH Terms
Cell Cycle
Cell Cycle Proteins / physiology*
Chromosomal Instability*
DNA / metabolism
DNA Damage
DNA Replication
G1 Phase*
Models, Biological
Neoplasms / metabolism*
S Phase*
Signal Transduction
Reg. No./Substance:
0/Cell Cycle Proteins; 9007-49-2/DNA

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