| G protein-coupled receptor kinase 2 expression and activity are associated with blood pressure in black Americans. | |
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MedLine Citation:
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PMID: 19487588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension occurs with higher prevalence and morbidity in black Americans compared with other groups. Alterations in the signal transduction pathways of 7-transmembrane spanning receptors are found in hypertensive patients. G protein-coupled receptor kinases (GRKs) play an important role in regulating this receptor signaling. The 2 most abundantly expressed GRKs in the cardiovascular system are GRK2 and GRK5, and each has unique substrates. Understanding changes in expression may give us insight into activated receptors in the pathophysiological progression of hypertension. In heart failure and white hypertensives, increased GRK2 expression arises because of neurohormonal stimulation of particular receptors. GRK2 subsequently desensitizes specific receptors, including beta-adrenergic receptors. In blood pressure control, beta-adrenergic receptor desensitization could lead to increased blood pressure. GRK2 and GRK5 mRNA were evaluated in lymphocytes of black Americans via quantitative real-time PCR. GRK2 mRNA expression directly correlated with systolic blood pressure and norepinephrine levels. GRK2 was elevated >30% among those with systolic blood pressure > or =130 mm Hg. No significant correlation between GRK5 mRNA expression and blood pressure or catecholamines was observed. Diabetic status, age, sex, and body mass index were also compared with GRK2 expression using univariate and multivariate analyses. GRK2 protein expression was elevated 2-fold in subjects with higher blood pressure, and GRK activity was increased >40%. Our data suggest that GRK2, but not GRK5, is correlated with increasing blood pressure in black Americans. Understanding the receptors stimulated by increased neurohormonal activation may give insight into the pathophysiology of hypertension in this at-risk population. |
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Authors:
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Heather I Cohn; Yihuan Xi; Stephanie Pesant; David M Harris; Terry Hyslop; Bonita Falkner; Andrea D Eckhart |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-06-01 |
Journal Detail:
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Title: Hypertension Volume: 54 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-18 Completed Date: 2009-09-16 Revised Date: 2012-06-07 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 71-6 Citation Subset: IM |
Affiliation:
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Center for Translational Medicine, Thomas Jefferson Hospital, Philadelphia, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult African Americans / statistics & numerical data* Aged Blood Pressure / physiology* Cohort Studies Female G-Protein-Coupled Receptor Kinase 2 / genetics, metabolism* G-Protein-Coupled Receptor Kinase 5 / genetics, metabolism* Gene Expression Regulation, Enzymologic Humans Hypertension / enzymology, ethnology, physiopathology Immunoassay Immunoblotting Male Middle Aged Multivariate Analysis Norepinephrine / blood Prevalence RNA, Messenger / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction United States / epidemiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK046107-08/DK/NIDDK NIH HHS; R01 DK046107-09/DK/NIDDK NIH HHS; R01 DK046107-10/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 51-41-2/Norepinephrine; EC 2.7.11.15/ADRBK1 protein, human; EC 2.7.11.15/G-Protein-Coupled Receptor Kinase 2; EC 2.7.11.16/G-Protein-Coupled Receptor Kinase 5; EC 2.7.11.16/GRK5 protein, human |
| Comments/Corrections | |
Comment In:
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Hypertension. 2009 Jul;54(1):27-8
[PMID:
19487585
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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