Document Detail


The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescents.
MedLine Citation:
PMID:  16940246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Approximately 20-40% of adolescents have shown a reduction of urinary sodium excretion (U(Na)V) in response to blood pressure (BP) increase during behavioral stress. G protein-coupled receptor kinase 4 (GRK4) mediates the pressure and natriuresis relation. The present study investigated the impact of GRK4 genetic variants on U(Na)V under stress. A total of 664 normotensive adolescents including whites and blacks (17.6 +/- 3.3 yrs, 43.4% blacks) were recruited. Participants were subjected to a stress-protocol including three 10-min tasks (a social competence interview, a virtual reality car driving simulation test, and a video game challenge), concluded by a urine collection. Three functional polymorphisms including R65L, A142V and A486V were genotyped. Given blacks compared with whites had significantly higher systolic BP (SBP) levels during rest (p < 0.001) and stress (p <or= 0.001), there was no statistical difference in U(Na)V in response to stress between the two ethnic groups. In blacks, compared with R65R homozygotes, individuals with R65L or L65L genotype had significantly lower levels of stress-induced U(Na)V (8.42 +/- 0.63 versus 9.85 +/- 0.37 mEq/h, p = 0.01). In summary, BP elevation seems uncoupled with U(Na)V increase during behavioral stress in black adolescents. The 65L allele of the GRK4 gene is associated with stress-induced U(Na)V reduction, suggesting impaired sodium handling in affected black youth.
Authors:
Haidong Zhu; Yanhui Lu; Xiaoling Wang; Harold Snieder; Frank A Treiber; Gregory A Harshfield; Yanbin Dong
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study     Date:  2006-08-28
Journal Detail:
Title:  Pediatric research     Volume:  60     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2006-10-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  440-2     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912-3715, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
African Continental Ancestry Group / genetics*
Blood Pressure
Female
G-Protein-Coupled Receptor Kinase 4
Humans
Male
Polymorphism, Genetic
Protein-Serine-Threonine Kinases / genetics,  physiology*
Sodium / metabolism,  urine*
Stress, Psychological / enzymology,  metabolism*
Grant Support
ID/Acronym/Agency:
HL076723/HL/NHLBI NIH HHS; HL69999/HL/NHLBI NIH HHS; R01HL56622/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7440-23-5/Sodium; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.16/G-Protein-Coupled Receptor Kinase 4; EC 2.7.11.16/GRK4 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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