| G protein-coupled receptor dimers: look like their parents, but act like teenagers! | |
| | |
MedLine Citation:
|
PMID: 23323734 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract G protein-coupled receptors (GPCRs) represent the largest group of cell surface receptors and an important pharmacological target. Though originally thought to act in a one receptor-one effector fashion, it is now known that these receptors are capable of oligomerization and can function as dimers or higher order oligomers in native tissue. They do not only assemble with identical receptors as homodimers, but also associate with different GPCRs to form heterodimers. We discuss here how heterodimeric GPCRs can assemble, traffic and signal in a manner distinct from their individual receptor components or from homodimers. These receptor pairs are also demonstrated to be regulated by different chaperones, Rabs and scaffolding proteins, further emphasizing their potential as unique targets. We believe in the importance of investigating each GPCR heterodimer as an individual signaling complex, as they appear to act differently from each monomer constituting them. Just as teenagers may resemble their parents and share their genetic makeup, they can still act in a manner that is entirely unique! |
| | |
Authors:
|
Jaime Wertman; Denis J Dupré |
Related Documents
:
|
7690404 - Selective antagonism of native and cloned kainate and nmda receptors by polyamine-conta... 2161774 - Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy. 6131834 - Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat... 23536824 - Computational study of synthetic agonist ligands of ionotropic glutamate receptors. 11376124 - The igf axis and hepatocarcinogenesis. 2943354 - Peripheral 5-ht2-like receptors. can they be classified with the available antagonists? |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-17 |
Journal Detail:
|
Title: Journal of receptor and signal transduction research Volume: - ISSN: 1532-4281 ISO Abbreviation: J. Recept. Signal Transduct. Res. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9509432 Medline TA: J Recept Signal Transduct Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pharmacology, Faculty of Medicine, Sir Charles Tupper Medical Building, Dalhousie University , Halifax, NS , Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: How Cholesterol Tilt Modulates the Mechanical Properties of Saturated and Unsaturated Lipid Membrane...
Next Document: SyntTax: a web server linking synteny to prokaryotic taxonomy.