| G protein beta3 subunit, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome. | |
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MedLine Citation:
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PMID: 20337945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The association between irritable bowel syndrome (IBS) based on Rome III criteria and G protein beta3 subunit (GNB3), interleukin (IL)-10, and tumor necrosis factor (TNF)-alpha gene polymorphisms is uncertain. METHODS: Case and control subjects were recruited from Korean visitors to the Health Promotion Center and Digestive Disease Center for gastrointestinal endoscopy. G protein beta3 subunit, IL-10, and TNF-alpha gene polymorphisms were genotyped using a polymerase chain reaction-based method. Multifactor dimensionality reduction (MDR) analysis was used to assess gene-gene interactions. KEY RESULTS: Genotype and allele frequencies of GNB3 showed marginal significance between the healthy controls and IBS patients (chi(2) = 5.92, P = 0.052; chi(2) = 3.76, P = 0.053). G protein beta3 subunit T allele was more strongly correlated with IBS with constipation (12 of constipation-dominant type and 31 of mixed type) than with 51 diarrhea-dominant type and 88 normal subjects (chi(2) = 13.91, P = 0.008). Multifactor dimensionality reduction analysis revealed that there were no significant interactions of GNB3, IL-10, and TNF-alpha gene variants with susceptibility to IBS (P > 0.05). CONCLUSIONS & INFERENCES: The results suggest that GNB3 825T allele might be associated with IBS with constipation in Koreans. |
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Authors:
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H-J Lee; S-Y Lee; J E Choi; J H Kim; I-K Sung; H S Park; C J Jin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-25 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 22 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 758-63 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Korea University College of Medicine, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alleles DNA / genetics Female Gene Frequency Genotype Heterotrimeric GTP-Binding Proteins / genetics* Humans Interleukin-10 / genetics* Irritable Bowel Syndrome / epidemiology*, genetics* Korea / epidemiology Male Middle Aged Polymorphism, Genetic / genetics Questionnaires Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha / genetics* |
| Chemical | |
Reg. No./Substance:
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0/G-protein beta3 subunit; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 9007-49-2/DNA; EC 3.6.5.1/Heterotrimeric GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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