| G-protein beta3 subunit gene variant (C825T) is unlikely to have a significant influence on serum total cholesterol level in Japanese workers. | |
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MedLine Citation:
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PMID: 16443564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the association between hypercholesterolemia or serum total cholesterol level and the C825T polymorphism in the G-protein ss3 subunit gene in Japanese workers using multivariate analysis to control possible confounding factors. The study subjects were 1,452 males and 1,169 females selected from 3,834 males and 2,591 females. Hypercholesterolemia was classified as either a total serum cholesterol $5.7 mmol/L (220 mg/dL) or taking lipid-lowering medication. The statistical power of the study was estimated as 99.9% based on total cholesterol levels of previous significant studies in Caucasians and Japanese. The genotype distributions in males with hypercholesterolemia (CC = 78, CT = 154, TT = 78) and females (CC = 60, CT = 137, TT = 52) were not significantly different from normal males (CC = 280, CT = 595, TT = 267) or females (CC = 234, CT = 501, TT = 185). Allele distributions also were not significantly different in either sex. Logistic regression analysis of hypercholesterolemia data and analysis of variance, t-test and multiple regression of serum total cholesterol data demonstrated no significant relationship with the C825T genotype. Despite sufficient statistical power, this study did not demonstrate a significant influence of C825T on hypercholesterolemia or serum total cholesterol level. The targeting of this polymorphism therefore is unlikely to be beneficial in preventing hypercholesterolemia in the general Japanese population. |
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Authors:
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Yasushi Suwazono; Etsuko Kobayashi; Mirei Uetani; Katsuyuki Miura; Yuko Morikawa; Masao Ishizaki; Teruhiko Kido; Hideaki Nakagawa; Koji Nogawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 28 ISSN: 1064-1963 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-30 Completed Date: 2006-03-02 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 47-56 Citation Subset: IM |
Affiliation:
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Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan. suwa@faculty.chiba-u.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Cholesterol / blood*, genetics* Cross-Sectional Studies Female Genetic Variation* Heterotrimeric GTP-Binding Proteins / genetics* Humans Hypercholesterolemia / blood, genetics* Japan Male Multivariate Analysis Polymorphism, Single Nucleotide |
| Chemical | |
Reg. No./Substance:
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0/G-protein beta3 subunit; 57-88-5/Cholesterol; EC 3.6.5.1/Heterotrimeric GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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