Document Detail


G-protein beta3 subunit gene splice variant in obesity and overweight.
MedLine Citation:
PMID:  11439289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) is associated with overweight and obesity. This polymorphism leads to a splice variant (Gbeta3-s) with higher activity and very strong association with essential hypertension.
DESIGN: A cross-sectional case-control study.
SUBJECTS: The sets of affected and control British/European Caucasian subjects used were: (i) an obesity clinic group most of whom had "morbid obesity" (mean body mass index (BMI) for group=43+/-8 kg/m(2)) and non-obese controls (BMI< or =30); (ii) a group of overweight/obese healthy normotensive community volunteers (BMI>25; mean 29+/-5) and controls (BMI< or =25; mean 23+/-1); (iii) a group of overweight/obese hypertensive patients (BMI>25; mean 30+/-4) and lean hypertensive controls (BMI< or =25; mean=23+/-2).
MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of GNB3 polymorphism.
RESULTS: Compared with control, frequency of the T allele in obese subjects was higher by 12% in (i), 17% in (ii) and 28% in (iii), but the differences were not statistically significant. Slight tracking of the T allele with elevation in BMI was, however, observed, in the obesity clinic group (P=0.018).
CONCLUSION: The C825T splice variant of GNB3 makes little if any contribution to obesity in the groups we tested.
Authors:
A V Benjafield; R C Lin; B Dalziel; A K Gosby; I D Caterson; B J Morris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  25     ISSN:  -     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-05     Completed Date:  2001-12-13     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  777-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure
Body Mass Index
Case-Control Studies
Cross-Sectional Studies
Female
Gene Frequency
Heterotrimeric GTP-Binding Proteins / genetics*
Humans
Hypertension / genetics*
Lipids / blood*
Male
Middle Aged
Obesity, Morbid / genetics*
Polymorphism, Genetic
Chemical
Reg. No./Substance:
0/Lipids; EC 3.6.5.1/Heterotrimeric GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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