| G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. | |
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MedLine Citation:
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PMID: 10461903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Components of cyclic AMP (cAMP) signaling were examined in postmortem cerebral cortex of a well characterized group of patients with mood disorders and nonpsychiatric control subjects. We measured G protein levels, adenylyl cyclase (AC) activity, and CREB levels in cerebral cortex of the subjects with respect to diagnosis, treatment, and suicide. There was no effect of diagnosis on any measure, except for a trend toward decreased stimulated AC activity in subjects with mood disorders relative to control subjects. We also detected a significant effect of suicide on temporal cortex CREB levels in subjects that died as a result of suicide relative to those that did not, which was more evident in patients with major depressive disorder. Bipolar disorder (BD) subjects treated with anticonvulsants at the time of death had decreased temporal cortex CREB levels relative to those not receiving anticonvulsants. Furthermore, we found a trend toward decreased occipital cortex G alpha(s) (short) levels in BD subjects treated with lithium. These results support the hypothesis of altered cAMP signaling in mood disorders and raise the possibility that factors other than diagnosis, such as treatment and suicide, may be relevant to cell-signaling abnormalities reported in the literature. |
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Authors:
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D Dowlatshahi; G M MacQueen; J F Wang; J S Reiach; L T Young |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurochemistry Volume: 73 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-09-14 Completed Date: 1999-09-14 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1121-6 Citation Subset: IM |
Affiliation:
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Mood Disorders Program, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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metabolism Adult Aged Antidepressive Agents / pharmacology*, therapeutic use Bipolar Disorder / metabolism Brain / drug effects, enzymology, metabolism* Cyclic AMP / physiology* Cyclic AMP Response Element-Binding Protein / metabolism Depressive Disorder / metabolism Female Forskolin / pharmacology GTP-Binding Protein alpha Subunits, Gi-Go / metabolism GTP-Binding Protein alpha Subunits, Gs / metabolism GTP-Binding Proteins / physiology* Humans Immunoblotting Male Middle Aged Mood Disorders / diagnosis, drug therapy, metabolism* Occipital Lobe / drug effects, metabolism Signal Transduction / physiology* Suicide* Temporal Lobe / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Cyclic AMP Response Element-Binding Protein; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; EC 3.6.1.-/GTP-Binding Proteins; EC 3.6.5.1/GTP-Binding Protein alpha Subunits, Gi-Go; EC 3.6.5.1/GTP-Binding Protein alpha Subunits, Gs; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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