| G-CSF-induced decrease of the anti-granulocyte autoantibody levels in a patient with autoimmune granulocytopenia. | |
| | |
MedLine Citation:
|
PMID: 9322685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We present a case of an 81-year-old man with secondary autoimmune granulocytopenia in association with autoimmune thrombocytopenia. Treatment with granulocyte colony-stimulating factor (G-CSF) (5 micrograms/ kg/day s.c.) resulted in a rapid increase in the number of circulating granulocytes with a pronounced left shift. These changes were accompanied by up-regulation of the surface expression of Fc gamma RI (CD64) and Fc gamma RII (CD32) on the granulocytes. In addition, we noted a strong up-regulation of the Fc gamma RIII (CD16) and the activation markers CD11b and CD66b on the granulocytes. The increase in the number of circulating granulocytes was followed by a dramatic decrease in the level of cell-bound as well as circulating anti-granulocyte antibodies. It is hypothezised that the decrease in the level of cell-bound as well as circulating anti-granulocyte antibodies may be the result of an increased adsorption of the antibodies by the granulocytes. |
| | |
Authors:
|
L T Vlasveld; M de Haas; A A Ermens; L Porcelijn; J A van Marion-Kievit; A E von dem Borne |
Related Documents
:
|
8884425 - Cellular and molecular analysis of lymphoid development using rag-deficient mice. 8986715 - Cd22 is both a positive and negative regulator of b lymphocyte antigen receptor signal ... 7005085 - E receptors and t antigens are different antigenic entities on human t lymphocytes. 10331185 - Development of a trispecific antibody conjugate that directs two distinct tumor-associa... 16185235 - Evaluation of taenia solium and taenia crassiceps cysticercal antigens for the serodiag... 19382845 - Preparation and characterization of a novel chimeric antibody against human cd40 with t... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Annals of hematology Volume: 75 ISSN: 0939-5555 ISO Abbreviation: Ann. Hematol. Publication Date: 1997 Jul-Aug |
Date Detail:
|
Created Date: 1997-10-28 Completed Date: 1997-10-28 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 59-64 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Diaconessenhuis, Eindhoven, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Agranulocytosis / blood, drug therapy*, immunology Autoantibodies / blood* Autoimmune Diseases / blood, drug therapy*, immunology Granulocyte Colony-Stimulating Factor / pharmacology, therapeutic use* Granulocytes / immunology* Humans Male Receptors, IgG / biosynthesis, genetics Thrombocytopenia / blood, drug therapy, immunology Up-Regulation / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Autoantibodies; 0/Receptors, IgG; 143011-72-7/Granulocyte Colony-Stimulating Factor |
| Comments/Corrections | |
Comment In:
|
Ann Hematol. 1998 Feb;76(2):93-4
[PMID:
9540766
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pericarditis induced by high-dose cytosine arabinoside chemotherapy.
Next Document: Late hemorrhagic disease of the newborn as a cause of intracerebral bleeding.