Document Detail

G-CSF-induced decrease of the anti-granulocyte autoantibody levels in a patient with autoimmune granulocytopenia.
MedLine Citation:
PMID:  9322685     Owner:  NLM     Status:  MEDLINE    
We present a case of an 81-year-old man with secondary autoimmune granulocytopenia in association with autoimmune thrombocytopenia. Treatment with granulocyte colony-stimulating factor (G-CSF) (5 micrograms/ kg/day s.c.) resulted in a rapid increase in the number of circulating granulocytes with a pronounced left shift. These changes were accompanied by up-regulation of the surface expression of Fc gamma RI (CD64) and Fc gamma RII (CD32) on the granulocytes. In addition, we noted a strong up-regulation of the Fc gamma RIII (CD16) and the activation markers CD11b and CD66b on the granulocytes. The increase in the number of circulating granulocytes was followed by a dramatic decrease in the level of cell-bound as well as circulating anti-granulocyte antibodies. It is hypothezised that the decrease in the level of cell-bound as well as circulating anti-granulocyte antibodies may be the result of an increased adsorption of the antibodies by the granulocytes.
L T Vlasveld; M de Haas; A A Ermens; L Porcelijn; J A van Marion-Kievit; A E von dem Borne
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of hematology     Volume:  75     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-10-28     Completed Date:  1997-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Department of Internal Medicine, Diaconessenhuis, Eindhoven, The Netherlands.
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MeSH Terms
Aged, 80 and over
Agranulocytosis / blood,  drug therapy*,  immunology
Autoantibodies / blood*
Autoimmune Diseases / blood,  drug therapy*,  immunology
Granulocyte Colony-Stimulating Factor / pharmacology,  therapeutic use*
Granulocytes / immunology*
Receptors, IgG / biosynthesis,  genetics
Thrombocytopenia / blood,  drug therapy,  immunology
Up-Regulation / drug effects
Reg. No./Substance:
0/Autoantibodies; 0/Receptors, IgG; 143011-72-7/Granulocyte Colony-Stimulating Factor
Comment In:
Ann Hematol. 1998 Feb;76(2):93-4   [PMID:  9540766 ]

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