Document Detail


G-CSF in the long-term treatment of cyclic neutropenia and chronic idiopathic neutropenia in adult patients.
MedLine Citation:
PMID:  8589368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eleven adult patients with chronic neutropenia have been treated with recombinant human granulocyte colony-stimulating factor (G-CSF). Seven patients had idiopathic sporadic neutropenia, 2 idiopathic congenital neutropenia and 2 cyclic neutropenia. Treatment was started with 3 micrograms/kg s.c. daily and was modified according to response. All patients had a rapid increase of neutrophils. The cycle length shortened from 21 to 14 days in patients with congenital cyclic neutropenia. Doses required for maintenance ranged from 0.1 to 8 micrograms/kg. One patient with idiopathic sporadic neutropenia recovered after 151 days with an absolute neutrophil count (ANC) of > 2000/microliters and had no need for further treatment. The overall efficacy of the treatment was good with abrogation of severe infections. Treatment has been continuously given to a maximum of 4.5 years. No loss of efficacy was observed during long-term treatment. There was no evidence for lineage drain or stem cell exhaustion with prolonged treatment. Cytogenetic analyses in seven of eleven patients did not reveal the development of abnormal cell-clones. G-CSF is safe and efficient in long-term treatment of adult patients with chronic neutropenias.
Authors:
P Heussner; D Haase; L Kanz; C Fonatsch; K Welte; M Freund
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of hematology     Volume:  62     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-03-27     Completed Date:  1996-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  225-34     Citation Subset:  IM    
Affiliation:
Department of Hematology, Hannover Medical School University Center, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Chronic Disease
Female
Filgrastim
Granulocyte Colony-Stimulating Factor / therapeutic use*
Humans
Male
Middle Aged
Neutropenia / drug therapy*,  etiology
Periodicity*
Recombinant Proteins / therapeutic use
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 121181-53-1/Filgrastim; 143011-72-7/Granulocyte Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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