Document Detail

Fuzzy logic controller for weaning neonates from mechanical ventilation.
MedLine Citation:
PMID:  12463838     Owner:  NLM     Status:  MEDLINE    
Weaning from mechanical ventilation is the gradual detachment from any ventilatory support till normal spontaneous breathing can be fully resumed. To date, we have developed a fuzzy logic controller for weaning COPD adults using pressure support ventilation (PS). However, adults and newborns differ in the pathophysiology of lung disease. We therefore used our fuzzy logic-based weaning platform to develop modularized components for weaning newborns with lung disease. Our controller uses the heart rate (HR), respiratory rate (RR), tidal volume (VT) and oxygen saturation (SaO2) and their trends deltaHR/deltat, deltaVT/deltat and deltaSaO2/deltat to evaluate, respectively, the Current and Trend weaning status of the newborn. Through appropriate fuzzification of these vital signs, Current and Trend weaning status can quantitatively determine the increase/decrease in the synchronized intermittent mandatory ventilation (SIMV) setting. The post-operative weaning courses of 10 newborns, 82+/-162 days old, were assessed at 2-hour intervals for 68+/-39 days. The SIMV levels, proposed by our algorithm, were matched to those levels actually applied. For 60% of the time both values coincided. For the remaining 40%, our algorithm suggested lower SIMV support than what was applied. The Area Under the Curve for integrated ventilatory support over time was 1203+/-846 for standard ventilatory strategies and 1152+/-802 for fuzzy controller. This suggests that the algorithm, approximates the actual weaning progression, and may advocate a more aggressive strategy. Moreover, the core of the fuzzy controller facilitates adaptation for body size and diversified disease patterns and sets the premises as an infant-weaning tool.
G E Hatzakis; G M Davis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings / AMIA ... Annual Symposium. AMIA Symposium     Volume:  -     ISSN:  1531-605X     ISO Abbreviation:  Proc AMIA Symp     Publication Date:  2002  
Date Detail:
Created Date:  2002-12-04     Completed Date:  2003-04-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100883449     Medline TA:  Proc AMIA Symp     Country:  United States    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.
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MeSH Terms
Area Under Curve
Fuzzy Logic*
Heart Defects, Congenital / physiopathology,  therapy
Heart Rate
Infant, Newborn*
Oxygen / blood
Respiration, Artificial
Respiratory Mechanics
Tidal Volume
Ventilator Weaning*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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