| Fuzeon-induced collagenophagic granuloma: a peculiar granulomatous injection site reaction to Fuzeon--a case report and review of literature. | |
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MedLine Citation:
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PMID: 19223380 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Enfuvirtide (ENF, T-20, or Fuzeon [Hoffman-La Roche Inc, Nutley, NJ, and Trimeris, Inc, Durham, NC]) is an HIV-1 fusion inhibitor and is the only injectable antiretroviral drug available. Injection site reactions (ISRs) are the most frequently reported adverse events, occurring in about 98% of patients. A granuloma annulare-like granulomatous ISR has been reported. We report a granulomatous ISR that is different from granuloma annulare and granuloma annulare-like reaction because it is rich in multinucleated giant cells engulfing altered collagen. We call this type of ISR a collagenophagic granuloma. Most previous reports-with the exception of 1 report-about ISRs with ENF treatment have used punch biopsies, which lack the depth to analyze the reticular dermis and subcutaneous tissue and, therefore, may have missed ISRs, which look like granuloma annulare, and the collagenophagic granulomatous reaction. |
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Authors:
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Harleen K Sidhu; Barbara H Chaffee; Christian D Tvetenstrand; Jagmohan S Sidhu |
Publication Detail:
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Type: Journal Article Date: 2009-02-17 |
Journal Detail:
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Title: International journal of surgical pathology Volume: 18 ISSN: 1940-2465 ISO Abbreviation: Int. J. Surg. Pathol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9314927 Medline TA: Int J Surg Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 384-7 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island 02903, USA. hsidhu@lifespan.org |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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