| Future potential biomarkers for postinterventional restenosis and accelerated atherosclerosis. | |
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MedLine Citation:
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PMID: 22296196 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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New circulating and local arterial biomarkers may help the clinician with risk stratification or diagnostic assessment of patients and selecting the proper therapy for a patient. In addition, they may be used for follow-up and testing efficacy of therapy, which is not possible with current biomarkers. Processes leading to postinterventional restenosis and accelerated atherosclerosis are complex due to the many biological variables mediating the specific inflammatory and immunogenic responses involved. Adequate assessment of these processes requires different and more specific biomarkers. Postinterventional remodeling is associated with cell stress and tissue damage causing apoptosis, release of damage-associated molecular patterns and upregulation of specific cytokines/chemokines that could serve as suitable clinical biomarkers. Furthermore, plasma titers of pathophysiological process-related (auto)antibodies could aid in the identification of restenosis risk or lesion severity. This review provides an overview of a number of potential biomarkers selected on the basis of their role in the remodeling process. |
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Authors:
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Jacco C Karper; Mark M Ewing; J Wouter Jukema; Paul Ha Quax |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomarkers in medicine Volume: 6 ISSN: 1752-0371 ISO Abbreviation: Biomark Med Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101312535 Medline TA: Biomark Med Country: England |
Other Details:
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Languages: eng Pagination: 53-66 Citation Subset: IM |
Affiliation:
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Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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