Document Detail

Future possibilities for conducting clinical trials to test the efficacy of beta-blocker medications.
MedLine Citation:
PMID:  6133639     Owner:  NLM     Status:  MEDLINE    
Beta-blocker therapy apparently is important in the short- and long-term care of patients with myocardial infarction (MI). In the former, administration may reduce MI size, and in the latter, it promotes a statistically significant reduction in mortality. Since beta blockers exert a number of effects, it is still not known how the specific beneficial effects are mediated. Nevertheless, there is still a need to examine the effects of beta blockers, either singly or combined with other medications, on patients recovering from acute MI and as a late intervention. Specific attention must be directed to the older patient, those with moderate myocardial dysfunction, and those with life-threatening ventricular dysrhythmias. Each of these problems must be addressed by a well-designed, randomized clinical trial to ensure the best possible study design and the most accurate scientific outcome.
J Naughton
Related Documents :
9277479 - Ace inhibitors and cardiac ace mrna in volume overload-induced cardiac hypertrophy.
22195279 - Aspirin: pharmacology and clinical applications.
22200369 - Early and late outcome after aortic root replacement with a mechanical valve prosthesis...
22727179 - Long-term follow-up of implantable cardioverter-defibrillator for secondary prevention ...
8247909 - The use of angiotensin-converting enzyme inhibitors after acute myocardial infarction.
18057309 - Association between serum 2-microglobulin level and infectious mortality in hemodialysi...
10955369 - Assessment of coagulation and platelet activation in coronary sinus blood induced by tr...
8661649 - Late thromboembolic complication from a palmaz stent in the common iliac artery.
3433879 - Morphologic evidence for "small vessel disease" in patients with hypertrophic cardiomyo...
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Circulation     Volume:  67     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I106-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Clinical Trials as Topic / methods
Drug Therapy, Combination
Middle Aged
Myocardial Infarction / drug therapy*,  physiopathology
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Alpha-adrenergic blockade for variant angina: a long-term, double-blind, randomized trial.
Next Document:  Multifactorial actions of beta-adrenergic blocking drugs in ischemic heart disease: current concepts...