| Future perspectives of articular cartilage repair. | |
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MedLine Citation:
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PMID: 18313478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extrapolating from the current state of the art in cartilage repair technology and basic science, we describe the future of regenerative medicine in the musculoskeletal system. Crucial milestones that have been recognized include supply with competent cells from autologous to xenogeneic sources, "intelligent" or "reactive" scaffold design, optimised application of humoral factors and the introduction of advanced gene-engineering technology. Besides these technical goals, ethical and legal considerations may significantly change the way pharmacological and medical components are recruited and regulated. At the same time, governmental regulatory bodies will have to accept new realities such as the existence of adaptive medical devices and of biological combination implants that are anywhere between a drug and a transplanted organ. For cartilage replacement itself, optimism seems to be justified regarding major advances within the next decade. |
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Authors:
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Christoph Gaissmaier; Jason L Koh; Kuno Weise; Juergen A Mollenhauer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Injury Volume: 39 Suppl 1 ISSN: 0020-1383 ISO Abbreviation: Injury Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2009-01-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0226040 Medline TA: Injury Country: Netherlands |
Other Details:
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Languages: eng Pagination: S114-20 Citation Subset: IM |
Affiliation:
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BG-Trauma Center, Eberhard-Karls-University, Schnarrenbergstrasse 95, Tübingen, Germany. gassmaier@tetec-ag.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arthroscopy
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methods Cartilage, Articular / metabolism, physiopathology* Chondrocytes / metabolism* Gene Therapy / methods, trends Humans Mesenchymal Stem Cell Transplantation / methods Osteoarthritis / physiopathology* Regeneration / physiology Tissue Engineering / methods, trends Transplantation, Autologous / methods*, trends Wound Healing / genetics, physiology* |
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