| Future horizons in surgical aortic valve replacement: lessons learned during the early stages of developing a transluminal implantation technique. | |
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MedLine Citation:
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PMID: 15307549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to develop a heart valve prosthesis that could be transluminally inserted through the infrarenal aorta in pigs and the femoral artery in humans. Therefore, this valve prosthesis had to be foldable to a diameter of approximately 8 mm, self-expandable when released in the vascular system, and equipped with an anchoring mechanism. For implantation, a suitable catheter delivery system for insertion via the abdominal aorta in pigs also was designed. Furthermore, an operation method, including positioning of the catheter delivery system and deployment of the valved stent under fluoroscopic and echocardiographic control, was developed. A series of different prototypes of the valved stents and catheter delivery systems was produced to optimize design and handling. These prototypes were tested in vitro in a circulation model, and those showing satisfying hemodynamic properties were implanted in pigs as in vivo studies afterwards. The valved stents had a good hemodynamic function in vitro and in vivo with no more than a mild regurgitation or stenosis. Valve movements were satisfying, and the design proved to be generally feasible. However, positioning and anchoring were still difficult; some stents were tilted in the lumen or migrated after implantation. |
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Authors:
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Daniela Kuklinski; Tim Attmann; Ernst Weigang; Jürgen Martin; Peter Osypka; Friedhelm Beyersdorf |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 50 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2004 Jul-Aug |
Date Detail:
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Created Date: 2004-08-13 Completed Date: 2004-10-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 364-8 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Surgery, School of Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta Aortic Valve / surgery* Equipment Design Foreign-Body Migration Heart Catheterization / methods Heart Valve Prosthesis / adverse effects Heart Valve Prosthesis Implantation / methods*, trends* Hemodynamics Mechanics Stents / adverse effects Swine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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