Document Detail

Future directions for nonclinical evaluation.
MedLine Citation:
PMID:  6407778     Owner:  NLM     Status:  MEDLINE    
Much of our knowledge about the effects of coronary occlusion and reperfusion is derived from studies in experimental animals. The recent discovery that coronary thrombosis is usually present in clinical myocardial infarction and that thrombolysis represents an approach to therapy presents opportunities for further experimental work. Animal models are particularly suited to the study of pathogenesis of thrombus formation in atherosclerotic vessels, the role of coronary vasomotor tone, and the effects of restoration of flow upon ischemic myocardium. Although the value of thrombolytic therapy must be proved in the clinical setting, animal models provide an important resource for the study of basic mechanisms.
W B Hood
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  68     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I98-104     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Platelets / pathology
Cardiomyopathies / etiology
Coronary Disease / complications,  pathology
Coronary Vasospasm / complications
Coronary Vessels / pathology
Disease Models, Animal*
Myocardial Infarction / etiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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