Document Detail

Future directions for clinical investigation in thrombolytic therapy.
MedLine Citation:
PMID:  6345024     Owner:  NLM     Status:  MEDLINE    
Experiments in animals have shown that coronary artery reperfusion limits the extent of myocardial damage and brings about late return of regional contraction and overall left ventricular function over a period of several weeks. Such studies provide a basis for optimism that similar effects can be demonstrated after thrombolytic treatment in man, and such functional contractile recovery should provide an important end point in clinical investigations. However, before the initiation of a large-scale clinical trial, adequate methods for determining salvage of myocardium must be identified, and since changes in such measures may be small, the use of mortality as an end point should also be considered. In addition, the possibility of having two treatment groups to compare intracoronary and intravenous modes of therapy should be examined. Based on the growing number of uncontrolled clinical reports concerned with the success of intracoronary thrombolysis in restoring vessel patency and preliminary data on morbidity, mortality and potential improvement in left ventricular function with this procedure, planning for a randomized clinical trial sponsored by the National Institutes of Health is warranted.
J Ross
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Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  68     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I105-9     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiomyopathies / etiology
Clinical Trials as Topic
Coronary Artery Bypass
Myocardial Contraction
Myocardial Infarction / complications,  drug therapy,  physiopathology,  therapy*
Random Allocation
Streptokinase / therapeutic use
Grant Support
Reg. No./Substance:
EC 3.4.-/Streptokinase

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