Document Detail

Future applications of antioxidants in premature infants.
MedLine Citation:
PMID:  21150443     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review will examine the unique susceptibility of premature infants to oxidative stress, the role of reactive oxygen species (ROS) in the pathogenesis of common disorders of the preterm infant, and potential for therapeutic interventions using enzymatic and/or nonenzymatic antioxidants.
RECENT FINDINGS: Oxidative stress is caused by an imbalance between the production of ROS and the ability to detoxify them with the help of antioxidants. The premature infant is especially susceptible to ROS-induced damage because of inadequate antioxidant stores at birth, as well as impaired upregulation in response to oxidant stress. Thus, the premature infant is at increased risk for the development of ROS-induced diseases of the newborn, such as bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and periventricular leukomalacia.
SUMMARY: Potential therapies for ROS-induced disease include both enzymatic and nonenzymatic antioxidant preparations. More research is required to determine the beneficial effects of supplemental antioxidant therapy.
Jennifer W Lee; Jonathan M Davis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  23     ISSN:  1531-698X     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-17     Completed Date:  2011-07-26     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  161-6     Citation Subset:  IM    
The Floating Hospital for Children at Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
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MeSH Terms
Antioxidants / therapeutic use*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy*,  metabolism*
Oxidative Stress / physiology*
Pregnancy Complications / etiology,  metabolism
Pregnancy Outcome
Premature Birth / metabolism
Reactive Oxygen Species / metabolism
Grant Support
R01 HL064158-01A1/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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