| The future of research and publication on altered H5N1 viruses. | |
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MedLine Citation:
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PMID: 22454474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, we and others obtained experimental evidence that highly pathogenic avian influenza virus subtype H5 can acquire the ability to transmit via aerosols between ferrets. Upon submission of manuscripts describing the results of these studies, the US National Science Advisory Board for Biosecurity was consulted and recommended that the main conclusions of the work be published but without the experimental details and mutation data that would enable replication of the experiments. Over the past few months, these events have led to intense discussions. Should this type of experiment be conducted? If so, under what conditions? Do the scientific and public health benefits of the work and its publication outweigh the potential risks? In February 2012, public health and influenza experts discussed these issues during a World Health Organization-organized technical consultation. This perspective article reviews the current state of the field and the recommendations made during the meeting. |
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Authors:
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Sander Herfst; Albert D M E Osterhaus; Ron A M Fouchier |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-03-27 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 205 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-10 Completed Date: 2012-07-09 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1628-31 Citation Subset: AIM; IM |
Affiliation:
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Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomedical Research / methods*, trends Disease Transmission, Infectious / prevention & control* Ferrets Humans Influenza A Virus, H5N1 Subtype / pathogenicity* Netherlands Orthomyxoviridae Infections / transmission* Publications / trends United States Zoonoses / transmission* |
| Grant Support | |
ID/Acronym/Agency:
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HHSN266200700010C//PHS HHS |
| Comments/Corrections | |
Comment In:
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J Infect Dis. 2012 Jun;205(11):1621
[PMID:
22454473
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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