Document Detail


Fusome asymmetry and oocyte determination in Drosophila.
MedLine Citation:
PMID:  7758245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Germline cysts containing 16 interconnected cells (cystocytes) are produced at an early stage of Drosophila oogenesis by progenitor cells known as cystoblasts that undergo four synchronous rounds of incomplete division. During cyst formation, a region of specialized, spectrin-rich cytoplasm called the fusome traverses the intercellular connections (ring canals), linking individual cystocytes. Subsequently, 15 cystocytes begin to transport specific RNAs and other components into the remaining cell, the future oocyte. We used fusome-specific antibodies to characterize the early stages of cyst formation. During the first cystoblast division, a spherical mass of fusome material (the "spectrosome") was associated with only one pole of the mitotic spindle, revealing that this division is asymmetric. During the subsequent three divisions, the growing fusome always associated with the pole of each mitotic spindle that remained in the mother cell, and only extended through the newly formed ring canals after each division was completed. These observations suggest that fusomes help establish a system of directional transport between cystocytes that underlies oocyte determination.
Authors:
H Lin; A C Spradling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental genetics     Volume:  16     ISSN:  0192-253X     ISO Abbreviation:  Dev. Genet.     Publication Date:  1995  
Date Detail:
Created Date:  1995-06-27     Completed Date:  1995-06-27     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7909963     Medline TA:  Dev Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6-12     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication
Cell Division
Cell Polarity
Cytoplasm / metabolism,  ultrastructure
Drosophila melanogaster / physiology*
Female
Mitotic Spindle Apparatus / physiology
Oocytes / cytology*
Oogenesis / physiology*
Organelles / immunology,  physiology*
Ovary / physiology,  ultrastructure
Spectrin / metabolism
Grant Support
ID/Acronym/Agency:
//Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
12634-43-4/Spectrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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