| Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. | |
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MedLine Citation:
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PMID: 9373237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chromosomal translocations involving band 5q31-35 occur in several hematologic disorders. A clone with a t(5; 14)(q33; q32) translocation appeared at the relapse phase in a patient with acute myelogenous leukemia who exhibited a sole chromosomal translocation, t(7; 11), at initial diagnosis. After the appearance of this clone, the leukemia progressed with marked eosinophilia, and combination chemotherapy was ineffective. Southern blot analysis showed a rearrangement of the platelet-derived growth factor receptor beta (PDGFRbeta) gene at 5q33 which was not observed at initial diagnosis. This translocation resulted in a chimeric transcript fusing the PDGFRbeta gene on 5q33 with a novel gene, CEV14, located at 14q32. Expression of the 5' region of the PDGFRbeta cDNA, upstream of the breakpoint, was not detected. However, the 3' region of PDGFRbeta, which was transcribed as part of the CEV14-PDGFRbeta fusion gene, was detected. A partial cDNA for a novel gene, CEV14, includes a leucine zipper motif and putative thyroid hormone receptor interacting domain and is expressed in a wide range of tissues. The expression of a CEV14-PDGFRbeta fusion gene in association with aggressive leukemia progression suggests that this protein has oncogenic potential. |
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Authors:
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A Abe; N Emi; M Tanimoto; H Terasaki; T Marunouchi; H Saito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood Volume: 90 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1997-12-23 Completed Date: 1997-12-23 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4271-7 Citation Subset: AIM; IM |
Affiliation:
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First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya; Mitsubishi Bioclinical Laboratory Inc, Tokyo. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Base Sequence Chromosomes, Human, Pair 14* Chromosomes, Human, Pair 5* Clone Cells / chemistry Eosinophilia / genetics, pathology Humans In Situ Hybridization, Fluorescence Leukemia, Myeloid, Acute / genetics*, pathology Molecular Sequence Data Nuclear Proteins* Oncogene Proteins, Fusion / chemistry, genetics* Platelet-Derived Growth Factor* Polymerase Chain Reaction Proteins / chemistry, genetics* Receptor, Platelet-Derived Growth Factor beta Receptors, Platelet-Derived Growth Factor / genetics* Translocation, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/CEV14-PDGFRbeta fusion protein, human; 0/Nuclear Proteins; 0/Oncogene Proteins, Fusion; 0/Platelet-Derived Growth Factor; 0/Proteins; 0/TRIP11 protein, human; EC 2.7.10.1/Receptor, Platelet-Derived Growth Factor beta; EC 2.7.10.1/Receptors, Platelet-Derived Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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