Document Detail

Fusion of phospholipid vesicles induced by phospholipase D in the presence of calcium ion.
MedLine Citation:
PMID:  1417878     Owner:  NLM     Status:  MEDLINE    
Fusion of phospholipid vesicles composed of various combination of phosphatidylcholine, phosphatidylethanolamine and phosphatidic acid was induced by Ca2+ in the presence or absence of phospholipase D from Streptomyces chromofuscus. For the vesicles composed of 20:50:30 molar ratio of phosphatidylcholine/phosphatidylethanolamine/phosphatidic acid, the initial fusion rate was much faster than the expected value when only the conversion of phosphatidylcholine and phosphatidylethanolamine into phosphatidic acid by phospholipase D is taken into account. These observations are discussed in terms of the involvement of outer monolayer of the vesicles and the enzyme activity itself in the fusion process.
J B Park; T H Lee; H Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemistry international     Volume:  27     ISSN:  0158-5231     ISO Abbreviation:  Biochem. Int.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-11-20     Completed Date:  1992-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100311     Medline TA:  Biochem Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  417-22     Citation Subset:  IM    
Department of Life Science, Korea Advanced Institute of Science and Technology, Yuseong-Gu, Taejon.
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MeSH Terms
Calcium / pharmacology*
Drug Synergism
Membrane Fusion / drug effects*
Phosphatidic Acids / metabolism
Phosphatidylcholines / metabolism
Phosphatidylethanolamines / metabolism
Phospholipase D / pharmacology*
Reg. No./Substance:
0/Liposomes; 0/Phosphatidic Acids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 7440-70-2/Calcium; EC D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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