Document Detail

Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors.
MedLine Citation:
PMID:  3935328     Owner:  NLM     Status:  MEDLINE    
An inversion of chromosome 14, inv(14)(q11,q32), is frequently observed in human T cell tumors; the cytogenetic breakpoints are of interest because the T cell receptor alpha-chain and immunoglobulin heavy chain genes reside on chromosome bands 14q11 and 14q32, respectively. We have investigated the structure of the alpha-chain genes in a T cell line harboring the chromosome 14 inversion. On the normal chromosome 14, a V alpha segment has rearranged nonproductively with a J alpha segment. In contrast, the inverted chromosome features an unprecedented rearrangement in which an immunoglobulin heavy chain variable gene segment (VH) on chromosome band 14q32 has joined with a J alpha segment from band 14q11. The VH-J alpha C alpha rearrangement is productive at the genomic level and therefore may encode a hybrid immunoglobulin/T cell receptor polypeptide.
R Baer; K C Chen; S D Smith; T H Rabbitts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  43     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-02-11     Completed Date:  1986-02-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  705-13     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M12070;  M12071;  M12072
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MeSH Terms
Base Sequence
Cell Line
Chromosome Inversion*
Chromosomes, Human, 13-15 / ultrastructure*
Immunoglobulin Heavy Chains / genetics*
Immunoglobulin J-Chains / genetics*
Immunoglobulin Variable Region / genetics*
Lymphoma / genetics*
Receptors, Antigen, T-Cell / genetics*
Reg. No./Substance:
0/Immunoglobulin Heavy Chains; 0/Immunoglobulin J-Chains; 0/Immunoglobulin Variable Region; 0/Receptors, Antigen, T-Cell

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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