Document Detail

Fusion of bone marrow-derived stem cells with striated muscle may not be sufficient to activate muscle genes.
MedLine Citation:
PMID:  15578085     Owner:  NLM     Status:  MEDLINE    
Several studies have demonstrated the existence of pluripotent bone marrow-derived stem cells capable of homing to injured cardiac and skeletal muscle; however, there has been little evidence demonstrating the induction of tissue-specific endogenous genes in donor stem cells following engraftment. A new study in this issue reports an intriguing finding that raises additional concerns relating to stem cell plasticity and stem cell therapy in an already heated and controversial field. The study demonstrates that wild-type bone marrow-derived side population stem cells are indeed readily incorporated into both skeletal and cardiac muscle when transplanted into mice that lack delta-sarcoglycan -- a model of cardiomyopathy and muscular dystrophy. However, these cells fail to express sarcoglycan and thus to repair the tissue, which suggests that this stem cell population has limited potential for cardiac and skeletal muscle regeneration.
Giulio Cossu
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  114     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-03     Completed Date:  2005-02-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1540-3     Citation Subset:  AIM; IM    
Stem Cell Research Institute, DIBIT, Milan, Italy.
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MeSH Terms
Cell Fusion
Gene Expression Regulation*
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells / cytology,  physiology*
Muscle, Skeletal / cytology,  physiology*
Myocardium / cytology,  metabolism
Pluripotent Stem Cells / physiology*
Regeneration / physiology
Sarcoglycans / genetics,  metabolism
Reg. No./Substance:
Comment On:
J Clin Invest. 2004 Dec;114(11):1577-85   [PMID:  15578090 ]

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