Document Detail


Fusidic acid in dermatology: an updated review.
MedLine Citation:
PMID:  20007058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies on the clinical efficacy of fusidic acid in skin and soft-tissue infections (SSTIs), notably those due to Staphylococcus aureus, are reviewed. Oral fusidic acid (tablets dosed at 250 mg twice daily, or a suspension for paediatric use at 20 mg/kg/day given as two daily doses) has shown good efficacy and tolerability. Similarly, plain fusidic acid cream or ointment used two or three times daily in SSTIs such as impetigo are clinically and bacteriologically effective, with minimal adverse events. Combination formulations of fusidic acid with 1% hydrocortisone or 0.1% betamethasone achieve excellent results in infected eczema by addressing both inflammation and infection. A new lipid-rich combination formulation provides an extra moisturizing effect. Development of resistance to fusidic acid has remained generally low or short-lived and can be minimized by restricting therapy to no more than 14 days at a time.
Authors:
Helmut Sch?fer; Lene Simonsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-12-14
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  20     ISSN:  1167-1122     ISO Abbreviation:  Eur J Dermatol     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  France    
Other Details:
Languages:  eng     Pagination:  6-15     Citation Subset:  IM    
Affiliation:
Dept. of Dermatovenereology, University Hospital der J. W. Goethe-University, 60590 Frankfurt/Main, Germany. schoefer@em.uni-frankfurt.de
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Administration, Topical
Anti-Bacterial Agents / administration & dosage,  therapeutic use*
Drug Combinations
Fusidic Acid / administration & dosage,  therapeutic use*
Glucocorticoids / administration & dosage
Humans
Skin Diseases, Infectious / drug therapy*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Drug Combinations; 0/Glucocorticoids; 6990-06-3/Fusidic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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