Document Detail

'Fusel' alcohols induce hyphal-like extensions and pseudohyphal formation in yeasts.
MedLine Citation:
PMID:  8704979     Owner:  NLM     Status:  MEDLINE    
At a concentration of 0.5% (v/v), isoamyl alcohol induced the formation of hyphal-like extensions in haploid and diploid strains of Saccharomyces cerevisiae in liquid complex medium. These extensions, which develop via bud initiation and elongation, undergo DNA replication and nuclear division and appear similar in many respects to an aberrant form of the cell division cycle. However, in 0.25% (v/v) isoamyl alcohol, S. cerevisiae formed pseudohyphae. Other 'fusel' alcohols (which are the products of amino acid catabolism) also induced hyphal-like extensions in this yeast, with n-amyl alcohol being as equally effective as isoamyl alcohol. Isoamyl alcohol induced the formation of pseudohyphae in two species of Candida and both hyphal-like extensions and pseudohyphae in Brettanomyces anomalus, suggesting a close relationship or a common basis to the development of the two morphologies.
J R Dickinson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Microbiology (Reading, England)     Volume:  142 ( Pt 6)     ISSN:  1350-0872     ISO Abbreviation:  Microbiology (Reading, Engl.)     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-09-12     Completed Date:  1996-09-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9430468     Medline TA:  Microbiology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1391-7     Citation Subset:  IM    
School of Pure and Applied Biology, University of Wales Cardiff, UK.
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MeSH Terms
1-Propanol / pharmacology
Alcohols / metabolism,  pharmacology*
Butanols / pharmacology
Cell Division
DNA Replication
DNA-Binding Proteins*
Ethanol / metabolism,  pharmacology
Fungal Proteins / metabolism
Hexanols / pharmacology
Isoleucine / metabolism
Leucine / metabolism
Methanol / pharmacology
Nitrogen / metabolism
Pentanols / pharmacology*
Phenylethyl Alcohol / pharmacology
Protein Kinases / metabolism
Saccharomyces cerevisiae / drug effects*,  growth & development,  ultrastructure
Saccharomyces cerevisiae Proteins*
Species Specificity
Valine / metabolism
Yeasts / drug effects,  metabolism
Reg. No./Substance:
0/Alcohols; 0/Butanols; 0/DNA-Binding Proteins; 0/Fungal Proteins; 0/Hexanols; 0/Pentanols; 0/Saccharomyces cerevisiae Proteins; 111-27-3/1-hexanol; 123-51-3/isopentyl alcohol; 60-12-8/Phenylethyl Alcohol; 61-90-5/Leucine; 64-17-5/Ethanol; 67-56-1/Methanol; 7004-03-7/Valine; 71-23-8/1-Propanol; 73-32-5/Isoleucine; 7727-37-9/Nitrogen; EC 2.7.-/Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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