Document Detail


Fused in sarcoma/translocated in liposarcoma: a multifunctional DNA/RNA binding protein.
MedLine Citation:
PMID:  20541619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fused in sarcoma/translocated in liposarcoma (FUS/TLS) gene was initially identified as a component of a fusion pro-oncogene resulting from a chromosomal translocation seen in liposarcomas. FUS/TLS belongs to a sub-family of RNA binding proteins, encoding an N-terminal serine-tyrosine-glycine-glutamine (SYGQ) region, an RNA recognition motif (RRM) flanked by glycine rich (G-rich) regions, a cysteine(2)/cysteine(2) zinc finger motif and multiple RGG repeats. The FUS/TLS protein interacts with RNA, single stranded DNA and double stranded DNA, and is involved in unique functions in mRNA processing and transport, transcriptional regulation and maintenance of genomic stability. Recently, several mutations in this gene have been found in amyotrophic lateral sclerosis (ALS) patients. The mutant forms of FUS/TLS exhibit similar pathology to other ALS causative genes, including aberrant cytoplasmic inclusions and an increased FUS/TLS cytoplasmic to nuclear ratio. The FUS/TLS mutations identified in ALS patients suggests that altered RNA metabolism may play a role in ALS pathogenesis.
Authors:
Shu Yang; Sadaf T Warraich; Garth A Nicholson; Ian P Blair
Related Documents :
17869269 - X-ray structure of a nf-kappab p50/relb/dna complex reveals assembly of multiple dimers...
9628329 - M.taqi: possible catalysis via cation-pi interactions in n-specific dna methyltransfera...
8415639 - I kappa b alpha-mediated inhibition of v-rel dna binding requires direct interaction wi...
18029709 - Dimerization-based homogeneous fluorosensor proteins for the detection of specific dsdna.
19063859 - Functional importance of the conserved n-terminal domain of the mitochondrial replicati...
8125259 - A sequence-specific, single-strand binding protein activates the far upstream element o...
23795299 - Rad51, friend or foe?
9339559 - Beta ray-induced scission of dna in tritiated water and protection by a green tea perco...
9092549 - Deletion analysis of the large subunit p140 in human replication factor c reveals regio...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-10
Journal Detail:
Title:  The international journal of biochemistry & cell biology     Volume:  42     ISSN:  1878-5875     ISO Abbreviation:  Int. J. Biochem. Cell Biol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508482     Medline TA:  Int J Biochem Cell Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1408-11     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Northcott Neuroscience Laboratory, ANZAC Research Institute, NSW, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amyotrophic Lateral Sclerosis / genetics,  metabolism
Animals
DNA-Binding Proteins / genetics,  metabolism*
Humans
Liposarcoma / physiopathology*
Models, Biological
Neurodegenerative Diseases / genetics,  metabolism
RNA-Binding Protein FUS / genetics,  metabolism*
RNA-Binding Proteins / genetics,  metabolism*
Sarcoma / physiopathology*
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/RNA-Binding Protein FUS; 0/RNA-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Perspectives on carbonic anhydrase.
Next Document:  Variations in p53-like cDNA sequence are correlated with mussel haemic neoplasia: A potential molecu...