Document Detail

Fusarium proliferatum culture material alters several production and immune performance parameters in White Leghorn chickens.
MedLine Citation:
PMID:  8537614     Owner:  NLM     Status:  MEDLINE    
White Leghorn Cornell K-strain chicks (3 replicates of 16 per pen) were started at Day 7 on feed amended with Fusarium proliferatum culture material containing fumonisin B1, fumonisin B2, and moniliformin at 61, 10.5, and 42.7 ppm, respectively. Observed effects on performance of treated birds included reduced feed conversion at 2 wk, and reduced body weight of males and females up to 6 wk (P < or = .05). Splenic, thymic, and liver weights, normalized for body weight, were reduced (P < or = .05) with no change in bursa of Fabricius. No significant changes were observed histologically in the spleen, bursa, kidney, heart, liver, cecal tonsils, colon, or tibia. Significant suppression in total Ig and IgG levels occurred. Macrophages from treated chicks exhibited a 34% reduction in phagocytic activity. Natural killer cell activity was not affected. These findings, which showed that Fusarium toxins alter performance and immune end points in chickens, imply that chickens exposed to mycotoxins may be more susceptible to infectious diseases.
M A Qureshi; J D Garlich; W M Hagler; D Weinstock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Immunopharmacology and immunotoxicology     Volume:  17     ISSN:  0892-3973     ISO Abbreviation:  Immunopharmacol Immunotoxicol     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-02-08     Completed Date:  1996-02-08     Revised Date:  2009-05-14    
Medline Journal Info:
Nlm Unique ID:  8800150     Medline TA:  Immunopharmacol Immunotoxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  791-804     Citation Subset:  IM    
Department of Poultry Science, North Carolina State University, Raleigh 27695-7608, USA.
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MeSH Terms
Antibody Formation / drug effects
Body Weight / drug effects
Cyclobutanes / toxicity
Fusarium / pathogenicity*
Immunity / drug effects*
Macrophages / drug effects,  physiology
Mycotoxins / toxicity*
Organ Size / drug effects
Reg. No./Substance:
0/Cyclobutanes; 0/Fumonisins; 0/Mycotoxins; 116355-83-0/fumonisin B1; 116355-84-1/fumonisin B2; 31876-38-7/moniliformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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