| Fusaric acid increases melatonin levels in the weanling rat and in pineal cell cultures. | |
MedLine Citation:
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PMID: 9055876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fusaric acid (FA) is produced by several Fusarium species that commonly infect cereal grains and other agricultural commodities. FA in the feed of nursing dams is lactationally transferred to the suckling offspring and alters serotonin (5-hydroxytryptamine, 5HT) in the pineal gland of the neonate rat. 5HT is involved in melatonin (MEL) production by the pineal gland. MEL is a hormone important in reproduction and seasonality in animals. Therefore, the effects of FA on MEL in the serum and pineal gland of male and female 21-d-old weanling rats from dams on an FA diet were studied. MEL was measured by enzyme-linked immunosorbent assay (ELISA), which was standardized for directly measuring MEL in rat serum and pineal homogenates. At 200 ppm in the diet of nursing dams, FA increased serum MEL in both sexes. Results obtained from ELISA were supported by high-performance liquid chromatography (HPLC) analysis with fluorescence detection. MEL analysis of the pineal gland homogenates by ELISA and HPLC supported observations in the serum. Analogously, in pineal cell monolayer cultures, FA at 1 microM and 100 microM concentrations increased MEL in a dose-dependent manner as compared to the control cells. This is the first report that FA increases MEL in vivo and in vitro and suggests that FA contamination of diets may affect mechanisms involving MEL synthesis. |
Authors:
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A M Rimando; J K Porter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of toxicology and environmental health Volume: 50 ISSN: 0098-4108 ISO Abbreviation: J Toxicol Environ Health Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-03-31 Completed Date: 1997-03-31 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7513622 Medline TA: J Toxicol Environ Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 275-84 Citation Subset: IM |
Affiliation:
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Richard B. Russell Agricultural Research Center, Toxicology and Mycotoxin Research Unit, Athens, Georgia 30613, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Chromatography, High Pressure Liquid Diet Dopamine Agents / pharmacology* Enzyme-Linked Immunosorbent Assay Female Fusaric Acid / pharmacology* Male Melatonin / blood, metabolism* Pineal Gland / drug effects*, metabolism* Rats Rats, Sprague-Dawley Weaning |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agents; 536-69-6/Fusaric Acid; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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