| Further studies on the use of chicken embryo infections for the study of drug resistance in Eimeria tenella. | |
| | |
MedLine Citation:
|
PMID: 1012747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Infections in the chicken embryo have been used to study the development of drug resistance in an embryo adapted strain of E. tenella. Resistance was developed to decoquinate, clopidol and robenidine by serially passaging this strain, but evidence for the development of resistance to amprolium was inconclusive. Resistance to decoquinate developed more readily than to the other drugs. Attempts to increase resistance to clopidol, robenidine and amprolium by increasing the sporozoite inoculum and by the use of a mutagenic agent were unsuccesful. No cross-resistance was found between the 4 drugs. Drug resistant lines of the Houghton strain (H) of E. tenella, made resistant to the 4 anticoccidial drugs by passage in chickens, were found to be resistant when evaluated using chicken embryo infections. Lines made resistant to decoquinate were not controlled by any concentration of this drug, suggesting that resistance, once developed, was absolute and not dependent on drug concentration. Lines made resistant to robenidine, clopidol and amprolium, however, were controlled by higher drug concentrations suggesting that in this case resistance was dependent on drug concentration. |
| | |
Authors:
|
H D Chapman |
Related Documents
:
|
19814777 - Specificity and levels of nonhost resistance to nonadapted blumeria graminis forms in b... 295047 - Relative fitness of genotypes in a population of rattus norvegicus polymorphic for warf... 16658217 - Freezing injury in potato leaves. 21700007 - Diversity of lactic acid bacteria associated with traditional fermented dairy products ... 19633117 - Overexpression of the groesl operon enhances the heat and salinity stress tolerance of ... 20526457 - Genetic factors associated with mating system cause a partial reproductive barrier betw... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Parasitology Volume: 73 ISSN: 0031-1820 ISO Abbreviation: Parasitology Publication Date: 1976 Dec |
Date Detail:
|
Created Date: 1977-03-15 Completed Date: 1977-03-15 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0401121 Medline TA: Parasitology Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 275-82 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amprolium
/
pharmacology Animals Chick Embryo / parasitology Clopidol / pharmacology Decoquinate / pharmacology Drug Resistance Eimeria / drug effects* Methylnitronitrosoguanidine / pharmacology Robenidine / pharmacology |
| Chemical | |
Reg. No./Substance:
|
137-88-2/Amprolium; 18507-89-6/Decoquinate; 25875-51-8/Robenidine; 2971-90-6/Clopidol; 70-25-7/Methylnitronitrosoguanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Eimeria tenella: experimental studies on the development of resistance to robenidine.
Next Document: Laboratory studies with some older anticoccidials.