Document Detail

Further studies on the tachyphylaxis to DSCG. The effects of concentration and temperature.
MedLine Citation:
PMID:  73516     Owner:  NLM     Status:  MEDLINE    
The tachyphylaxis to DSCG's inhibition of anaphylactic histamine release has been demonstrated in passively sensitized rat lung fragments. The induction of tachyphylaxis appears to depend on the concentration of the drug and the length of pretreatment. Tachyphylaxis is relatively independent of the concentration of the second exposure to DSCG. The development of tachyphylaxis is highly temperature dependent; it can be prevented by cooling the tissues to 2-4 degrees C after a brief (30 sec) preincubation with DSCG. It is suggested that DSCG inhibits histamine release by binding to 'receptor' site(s). Once the site is occupied by DSCG, it is modified by a temperature-dependent process, thus losing the ability as a 'receptor' for inhibition of histamine release. The tachyphylaxis is the result of such a modification.
C P Sung; H L Saunders; E Lenhardt; L W Chakrin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  55     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1977  
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  385-94     Citation Subset:  IM    
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MeSH Terms
Cromolyn Sodium / analogs & derivatives,  pharmacology*
Dose-Response Relationship, Drug
Histamine Release / drug effects
Lung / immunology
Ovalbumin / pharmacology
Phenolsulfonphthalein / pharmacology
Time Factors
Reg. No./Substance:
143-74-8/Phenolsulfonphthalein; 15826-37-6/Cromolyn Sodium; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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