Document Detail


Further studies on periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder.
MedLine Citation:
PMID:  10584676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fourteen consecutive children who were newly diagnosed with attention-deficit hyperactivity disorder (ADHD) and who had never been exposed to stimulants and 10 control children without ADHD underwent polysomnographic studies to quantify Periodic Limb Movements in Sleep (PLMS) and arousals. Parents commonly gave both false-negative and false-positive reports of PLMS in their children, and a sleep study was necessary to confirm their presence or absence. The prevalence of PLMS on polysomnography was higher in the children with ADHD than in the control subjects. Nine of 14 (64%) children with ADHD had PLMS at a rate of >5 per hour of sleep compared with none of the control children (p <0.0015). Three of 14 children with ADHD (21%) had PLMS at a rate of >20 per hour of sleep. Many of the PLMS in the children with ADHD were associated with arousals. Historical sleep times were less for children with ADHD. The children with ADHD who had PLMS chronically got 43 minutes less sleep at home than the control subjects (p = 0.0091). All nine children with ADHD who had a PLMS index of >5 per hour of sleep had a long-standing clinical history of sleep onset problems (>30 minutes) and/or maintenance problems (more than two full awakenings nightly) thus meeting the criteria for Periodic Limb Movement Disorder (PLMD). None of the control children had a clinical history of sleep onset or maintenance problems. The parents of the children with ADHD were more likely to have restless legs syndrome (RLS) than the parents of the control children. Twenty-five of 28 biologic parents of the children with ADHD and all of the biologic parents of the control children were reached for interview. Eight of twenty-five parents of the children with ADHD (32%) had symptoms of RLS as opposed to none of the control parents (p = 0.011). PLMS may directly lead to symptoms of ADHD through the mechanism of sleep disruption. Alternative explanations for the association between ADHD and RLS/PLMS are that they are genetically linked, they share a common dopaminergic deficit, or both.
Authors:
D L Picchietti; D J Underwood; W A Farris; A S Walters; M M Shah; R E Dahl; L J Trubnick; M A Bertocci; M Wagner; W A Hening
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  14     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-20     Completed Date:  2000-01-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1000-7     Citation Subset:  IM    
Affiliation:
Pediatric Neurology, Carle Clinic, Urbana, Illinois, USA.
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MeSH Terms
Descriptor/Qualifier:
Arousal
Attention Deficit Disorder with Hyperactivity / diagnosis*,  genetics
Child
Child, Preschool
Female
Genetic Predisposition to Disease / genetics
Humans
Male
Nocturnal Myoclonus Syndrome / diagnosis*,  genetics
Polysomnography
Restless Legs Syndrome / diagnosis*,  genetics
Grant Support
ID/Acronym/Agency:
MH 41712/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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