Document Detail


Further studies of the norditerpene (+)-harringtonolide isolated from Cephalotaxus harringtonia var. drupacea: absolute configuration, cytotoxic and antifungal activities.
MedLine Citation:
PMID:  18523925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Harringtonolide (= hainanolide) is a complex polycyclic fused norditerpene isolated from CEPHALOTAXUS HARRINGTONIA var. DRUPACEA. In spite of its appealing biological properties - we measured an IC (50) of 43 nM on KB cells and a significant antifungal activity - its absolute configuration has not yet been firmly established. This was done herein using X-ray anomalous scattering after bromination of the tropone ring, unambiguously giving the stereochemistry 5 R,6 R,7 S,13 S,14 S,15 R,16 R. Detailed IN VITRO biological measurements are provided.
Authors:
Laurent Evanno; Akino Jossang; Julie Nguyen-Pouplin; Diane Delaroche; Patrick Herson; Mannan Seuleiman; Bernard Bodo; Bastien Nay
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Publication Detail:
Type:  Journal Article     Date:  2008-06-03
Journal Detail:
Title:  Planta medica     Volume:  74     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-07-07     Completed Date:  2008-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  870-2     Citation Subset:  IM    
Affiliation:
Laboratoire de Chimie et Biochimie des Substances Naturelles, Muséum National d'Histoire Naturelle, CNRS, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / isolation & purification
Antineoplastic Agents, Phytogenic / isolation & purification
Cell Line, Tumor
Cephalotaxus / chemistry*
Harringtonines / chemistry*,  isolation & purification
Humans
Molecular Conformation
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Antineoplastic Agents, Phytogenic; 0/Harringtonines; 64761-48-4/hainanolide

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