| Further studies of the norditerpene (+)-harringtonolide isolated from Cephalotaxus harringtonia var. drupacea: absolute configuration, cytotoxic and antifungal activities. | |
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MedLine Citation:
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PMID: 18523925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Harringtonolide (= hainanolide) is a complex polycyclic fused norditerpene isolated from CEPHALOTAXUS HARRINGTONIA var. DRUPACEA. In spite of its appealing biological properties - we measured an IC (50) of 43 nM on KB cells and a significant antifungal activity - its absolute configuration has not yet been firmly established. This was done herein using X-ray anomalous scattering after bromination of the tropone ring, unambiguously giving the stereochemistry 5 R,6 R,7 S,13 S,14 S,15 R,16 R. Detailed IN VITRO biological measurements are provided. |
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Authors:
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Laurent Evanno; Akino Jossang; Julie Nguyen-Pouplin; Diane Delaroche; Patrick Herson; Mannan Seuleiman; Bernard Bodo; Bastien Nay |
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Publication Detail:
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Type: Journal Article Date: 2008-06-03 |
Journal Detail:
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Title: Planta medica Volume: 74 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-07 Completed Date: 2008-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 870-2 Citation Subset: IM |
Affiliation:
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Laboratoire de Chimie et Biochimie des Substances Naturelles, Muséum National d'Histoire Naturelle, CNRS, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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isolation & purification Antineoplastic Agents, Phytogenic / isolation & purification Cell Line, Tumor Cephalotaxus / chemistry* Harringtonines / chemistry*, isolation & purification Humans Molecular Conformation |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Antineoplastic Agents, Phytogenic; 0/Harringtonines; 64761-48-4/hainanolide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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