| Further studies of lipid peroxidation in human paraquat poisoning. | |
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MedLine Citation:
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PMID: 3963949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In patients with subacute toxic reactions from paraquat poisoning (death within 11 to 41 days), the extent of lipid peroxidation, expressed as serum malondialdehyde level, was 2.7-fold higher (12.33 +/- 4.42 nmole/mL) before pulmonary fibrosis than that in normal controls (4.55 +/- 1.23 nmole/mL). The extent of lipid peroxidation in patients with acute toxic reactions (death within one to three days) was not elevated; these patients died of pulmonary edema and hemorrhage (acute respiratory distress), liver failure, renal failure, and adrenal necrosis. Remarkable high levels of paraquat (greater than 5 mg/L) were found in the urine, serum, and tissues of patients with acute toxic reactions; a small amount of paraquat was found in the serum or urine of patients with subacute toxic reactions five to 11 days after ingestion. Patients who survived had no elevation in lipid peroxidation. Administration of vitamin E (100 to 4,000 mg/day from the first hospital day) had no effect on survival. |
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Authors:
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T Yasaka; K Okudaira; H Fujito; J Matsumoto; I Ohya; Y Miyamoto |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of internal medicine Volume: 146 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-04-28 Completed Date: 1986-04-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 681-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Female Hemoperfusion Humans Lipid Peroxides / blood* Male Malondialdehyde / blood Middle Aged Paraquat / blood, poisoning* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Lipid Peroxides; 4685-14-7/Paraquat; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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