Document Detail


Further studies on the effect of retrobulbar epinephrine injection on ocular and optic nerve blood flow.
MedLine Citation:
PMID:  3956237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of retrobulbar epinephrine administration on ocular and optic nerve blood flow was studied in phakic rabbit eyes using a radioactive microsphere (85Sr) technique. Blood flow measurements were performed either 5 minutes or 30 minutes after retrobulbar injection of 10 microliter of a 2% (base) epinephrine bitartrate solution to the right eye of each rabbit. Blood flow was determined for the iris, scraped ciliary processes, choroid, retina, and optic nerve. Five minutes after retrobulbar injection, there was no statistically significant (P greater than 0.05) difference in epinephrine-treated eyes compared to contralateral control eyes that received 10 microliters of retrobulbar saline. Thirty minutes after injection, eyes receiving retrobulbar epinephrine had a statistically significant (P less than 0.05) fall in blood flow to the iris and scraped ciliary processes, but not to the choroid, retina, or optic nerve.
Authors:
W M Jay; M Z Aziz; K Green
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Current eye research     Volume:  5     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-25     Completed Date:  1986-04-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  63-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Choroid / blood supply
Ciliary Body / blood supply
Epinephrine / administration & dosage,  pharmacology*
Eye / blood supply*
Female
Injections
Iris / blood supply
Male
Optic Nerve / blood supply*
Rabbits
Regional Blood Flow / drug effects
Retinal Vessels / physiology
Grant Support
ID/Acronym/Agency:
EY04559/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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