Document Detail


Further studies on the effect of adenosine cyclic monophosphate derivatives on cell proliferation in the jejunal crypts of rat.
MedLine Citation:
PMID:  6299638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Cell proliferation in the jejunal crypt epithelium of rat was measured using a stathmokinetic technique. 2. Sodium butyrate was found to promote jejunal crypt cell proliferation. 3. N6, O2'-Dibutyryl cyclic adenosine monophosphate (cAMP), N6-monobutyryl-cAMP and N6-monobutyryl-8-bromo-cAMP were found to inhibit cell proliferation when compared to sodium butyrate treated tissues. 4. 8-Chlorophenylthio-cAMP was found to inhibit cell division when compared to untreated animals. 5. O2'-Monobutyryl cAMP and 8-bromo-cAMP were not found to inhibit cell proliferation.
Authors:
P J Tutton; D H Barkla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  9     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1982 Nov-Dec
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  671-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bucladesine / pharmacology
Cell Division / drug effects
Cyclic AMP / analogs & derivatives*,  pharmacology
Intestinal Mucosa / drug effects*
Jejunum / drug effects*
Male
Mitosis / drug effects
Rats
Rats, Inbred Strains
Vinblastine / pharmacology
Chemical
Reg. No./Substance:
362-74-3/Bucladesine; 60-92-4/Cyclic AMP; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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