Document Detail

Further studies on the clinical efficacy of Solanum xanthocarpum and Solanum trilobatum in bronchial asthma.
MedLine Citation:
PMID:  15551394     Owner:  NLM     Status:  MEDLINE    
The clinical efficacy of two herbs S. xanthocarpum and S. trilobatum in a dose of 300 mg tds for 3 days was investigated in mild to moderate bronchial asthma. Their effect was compared with standard bronchodilator drugs, salbutamol (4 mg) and deriphylline (200 mg). The respiratory function was assessed by measuring the peak expiratory flow rate (PEFR) using a mini peak flow meter. In addition, improvement in lung function was assessed by physical examination (rhonchi and crepitation) and other symptoms such as cough, breathlessness and sputum. S. xanthocarpum and S. trilobatum produced a progressive improvement in the ventilatory function of asthmatic individuals over 3 days. The scores for rhonchi, cough, breathlessness and sputum were decreased by these drug treatments. The improvement in PEFR and the reduction in other symptom scores clearly indicate a bronchodilator effect, a decrease of oedema and secretions in the airway lumen. The response to these herbs can be considered to be equivalent to that of deriphylline but less than salbutamol. No untoward effects were reported during the study. The present study further confirms the traditional use of these herbs in bronchial asthma.
S Govindan; S Viswanathan; V Vijayasekaran; R Alagappan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  18     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-12-01     Completed Date:  2005-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  805-9     Citation Subset:  IM    
Copyright Information:
Copyright 2004 John Wiley & Sons, Ltd.
Institute of Internal Medicine, Madras Medical College, Government General Hospital, Chennai 600 033, India.
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MeSH Terms
Asthma / drug therapy*,  pathology
Bronchodilator Agents / administration & dosage,  pharmacology*,  therapeutic use
Middle Aged
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Respiratory Function Tests
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Bronchodilator Agents; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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