Document Detail

Further studies on Barretts mucosa in baboons: metaplastic glandular cells produce sialomucin.
MedLine Citation:
PMID:  21036729     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In humans and in baboons, protracted gastro-esophageal reflux (GER) transforms the squamous-lined esophagus into columnar-lined (that is Barrett's mucosa, BM). Alcian blue stain (AB) is used to evidence sialomucin-producing goblet cells in human BM.
AIM: To assess the frequency and distribution of sialomucin-producing cells in BM in baboons.
MATERIALS AND METHODS: Sections from 137 consecutive baboon esophagi were alternatively stained with hematoxylin-eosin (H&E) and with AB (pH 2.5), without counterstain.
RESULTS: Out of 137 baboons, 131 (95.6%) had BM. Columnar and intramucosal glandular cells produced sialomucin in all 131 of these animals. Many BM cells were ballooned and filled with sialomucins, despite goblet cells not being found in H&E sections.
CONCLUSION: In humans, protracted GER is a disease requiring medication that may lead to BM; AB stains mainly goblet cells and occasional columnar cells in BM. In baboons, in contrast, BM is a natural postnatal process of adaptation to GER, triggered by regurgitation and rumination. AB stains all columnar and intra-mucosal glandular cells. Sialomucin-overstuffed cells were more frequent and larger in baboons than in humans. The extra load of sialomucin in BM might be an integrated part of the postnatal life-long process of adaptation to regurgitation and rumination in baboons.
Carlos A Rubio; Michael Owston; Abiel Orrego; Edward J Dick
Related Documents :
238899 - Adenylate and guanylate cyclase activities and cellular differentiation in rat small in...
872179 - The effect of a single injection of hydroxyurea on cell population kinetics in the smal...
2570139 - Functional activity of intestinal epithelium demonstrated by mrna in situ hybridization.
20144469 - Histochemical studies on mucin-rich cells in the digestive tract of a teleost, the buen...
13762549 - Stability of protein in intestinal epithelial cells.
7085769 - Isolation of hamster intestinal epithelial cells using hypoosmotic media and pvp.
6260819 - Sodium and rubidium uptake in cells transformed by rous sarcoma virus.
7567119 - Ft-ir spectroscopy study of perturbations induced by antibiotic on bacteria (escherichi...
6814759 - Isolation and enrichment of the gastric chief cells of the rat.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-12-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  4123-6     Citation Subset:  IM    
Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, 78245-0549, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Barrett Esophagus / metabolism*,  pathology*
Disease Models, Animal
Esophagus / metabolism,  pathology
Monkey Diseases / metabolism,  pathology
Mucous Membrane / metabolism,  pathology
Sialomucins / biosynthesis*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Significance of keratinocyte growth factor receptor in the proliferation of biliary tract cancer.
Next Document:  Overexpression of tissue inhibitor of metalloproteinase-1 gene correlates with poor outcomes in colo...