Document Detail


Further studies on Barretts mucosa in baboons: metaplastic glandular cells produce sialomucin.
MedLine Citation:
PMID:  21036729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In humans and in baboons, protracted gastro-esophageal reflux (GER) transforms the squamous-lined esophagus into columnar-lined (that is Barrett's mucosa, BM). Alcian blue stain (AB) is used to evidence sialomucin-producing goblet cells in human BM.
AIM: To assess the frequency and distribution of sialomucin-producing cells in BM in baboons.
MATERIALS AND METHODS: Sections from 137 consecutive baboon esophagi were alternatively stained with hematoxylin-eosin (H&E) and with AB (pH 2.5), without counterstain.
RESULTS: Out of 137 baboons, 131 (95.6%) had BM. Columnar and intramucosal glandular cells produced sialomucin in all 131 of these animals. Many BM cells were ballooned and filled with sialomucins, despite goblet cells not being found in H&E sections.
CONCLUSION: In humans, protracted GER is a disease requiring medication that may lead to BM; AB stains mainly goblet cells and occasional columnar cells in BM. In baboons, in contrast, BM is a natural postnatal process of adaptation to GER, triggered by regurgitation and rumination. AB stains all columnar and intra-mucosal glandular cells. Sialomucin-overstuffed cells were more frequent and larger in baboons than in humans. The extra load of sialomucin in BM might be an integrated part of the postnatal life-long process of adaptation to regurgitation and rumination in baboons.
Authors:
Carlos A Rubio; Michael Owston; Abiel Orrego; Edward J Dick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-12-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  4123-6     Citation Subset:  IM    
Affiliation:
Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, 78245-0549, USA. Carlos.Rubio@ki.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Barrett Esophagus / metabolism*,  pathology*
Disease Models, Animal
Esophagus / metabolism,  pathology
Monkey Diseases / metabolism,  pathology
Mucous Membrane / metabolism,  pathology
Papio
Sialomucins / biosynthesis*
Grant Support
ID/Acronym/Agency:
P51 RR013986/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Sialomucins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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