Document Detail

Further results on a multiple-testing procedure for clinical trials.
MedLine Citation:
PMID:  6671127     Owner:  NLM     Status:  MEDLINE    
O'Brien and Fleming (1979, Biometrics 35, 549-556) proposed a procedure for multiple testing in clinical trials for acute disease. We evaluated their procedure for chronic-disease models and found that it can be used without modification. Type I errors are unaltered and no loss of power is seen in comparison with single-sample procedures. However, average savings in sample size are less for the chronic-disease models than for the acute model. Finally, it is shown that for any specific disease model and fixed maximum number of inspections of the data, the percentage reduction in sample size can be readily predicted from the power.
D Seigel; R C Milton
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biometrics     Volume:  39     ISSN:  0006-341X     ISO Abbreviation:  Biometrics     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-05-24     Completed Date:  1984-05-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370625     Medline TA:  Biometrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  921-8     Citation Subset:  IM    
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MeSH Terms
Chronic Disease
Clinical Trials as Topic / methods*
Research Design*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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