Document Detail

Further observations on the empty "amnion sign".
MedLine Citation:
PMID:  20127965     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the positive predictive value of the empty "amnion sign" (visualization of an amnion without concomitant visualization of an embryo) for the diagnosis of early pregnancy failure. METHODS: Retrospective study of 882 1st trimester sonographic examinations with abnormal findings among women who were threatening to abort. Eight hundred six met the inclusion criteria. RESULTS: In the study cohort 286 (35.5%) had no identifiable embryo and 71 of those without an identifiable embryo had a visible amnion (24.8%). The breakdown of the mean sac diameter of the study cohort was as follows: those measuring less than 16 mm (n = 16); those measuring 16-20 mm (n = 20); those measuring 21 mm or more (n = 35). Sixty-eight of the 71 patients had adequate follow-up. Pregnancy failure was confirmed in all 68 patients (positive predictive value = 100%). CONCLUSIONS: The data from this study indicate that visualization of an amnion without concomitant visualization of an embryo (the empty "amnion sign") confirms pregnancy failure regardless of the mean sac diameter and with a sufficiently high positive predictive value to make a definitive diagnosis.
N Tugce Yegul; Roy A Filly
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical ultrasound : JCU     Volume:  38     ISSN:  1097-0096     ISO Abbreviation:  J Clin Ultrasound     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401663     Medline TA:  J Clin Ultrasound     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Wiley Periodicals, Inc.
Department of Radiology, University of California, San Francisco, L374, 505 Parnassus Avenue, San Francisco, CA 94143-0628, USA.
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MeSH Terms
Amnion / ultrasonography*
Cohort Studies
Embryo Loss / ultrasonography*
Predictive Value of Tests
Pregnancy Trimester, First*
Reproducibility of Results
Retrospective Studies
Ultrasonography, Prenatal / methods*

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