Document Detail

Further investigation of secondary venous obstruction.
MedLine Citation:
PMID:  1406229     Owner:  NLM     Status:  MEDLINE    
The first ischemic insult a tissue suffers is primary (1 degree). A second ischemic episode, such as thrombosis after free tissue transfer may be regarded as secondary (2 degrees) ischemia. The current study investigated 2 degrees ischemia in rodent epigastric flaps. Flaps were elevated in 50 Sprague-Dawley rats: group 1 had 5 hours 1 degree venous ischemia induced by placement of microvascular clamps; group 2 was like group 1, except venous continuity was re-established by venous anastomosis after resection of the venous segment previously microclamped; group 3 had 15 minutes of 1 degree ischemia, 24 hr later 5 hr of 2 degrees venous ischemia was induced by placement of microvascular clamps; group 4 was like group 3, except the venous segment was excised. Necrosis was evaluated on postoperative day 7. Both secondary ischemic groups had significantly less flap survival than the corresponding primary ischemic groups (P less than 0.001 for both). Resection of a portion of the vein and subsequent microanastomosis did not reduce flap survival (NS). Secondary venous ischemia of 5-hr duration is poorly tolerated by rodent skin flaps. There was no difference in flap survival in those flaps whose veins were clamped for 5 hr compared to those flaps whose clamped venous segments were resected and re-anastomosed.
M F Angel; K R Knight; L R Amiss; R F Morgan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Microsurgery     Volume:  13     ISSN:  0738-1085     ISO Abbreviation:  Microsurgery     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-05     Completed Date:  1992-11-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8309230     Medline TA:  Microsurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-7     Citation Subset:  IM    
Division of Plastic Surgery, Johns Hopkins Medical School, Baltimore, MD 21205.
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MeSH Terms
Anastomosis, Surgical
Graft Survival
Ischemia / physiopathology*
Rats, Sprague-Dawley
Regional Blood Flow
Skin / blood supply
Surgical Flaps*
Veins / physiopathology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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