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Further insights on diastolic dysfunction in first trimester trisomy 21 fetuses.
MedLine Citation:
PMID:  24706444     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to assess fetal cardiac function in first trimester trisomy 21 fetuses as compared with fetuses with other aneuploidies, euploid fetuses with cardiac defects or isolated increased nuchal translucency and controls.
STUDY DESIGN: During a 2-year period,nuchal translucency (NT), ductus venosus (DV) blood flow, diastolic filling time (FT), early filling time (eT), tricuspid flow, tricuspid and mitral valve E/A velocity ratios, left ventricle shortening fraction (LVSF), left myocardial performance index (LMPI), and the fetal heart rate (FHR) were assessed in fetuses with a crown-rump length (CRL) between 45 and 84 mm undergoing chorionic villi sampling in our center. Cardiac parameters among study groups were compared with the use of 95% confidence intervals (95% CI).
RESULTS: The study population included 28 fetuses with trisomy 21, 25 with other aneuploidies, 94 euploid fetuses with abnormal findings (27 with cardiac defects, 31 with other structural anomalies, and 36 with isolated increased NT) and 271 controls. Trisomy 21 fetuses showed signs of diastolic dysfunction such as increased DV pulsatility index and E/A ratios together with a higher prevalence of tricuspid regurgitation. Conversely, no differences were found in euploid fetuses with cardiac defects or isolated increased NT.
CONCLUSIONS: No cardiac dysfunction signs were observed in euploid fetuses with increased NT or cardiac defects, while in trisomy 21 diastolic dysfunction signs could be potentially attributed to volume overload.
Authors:
Mula Raquel; Grande Maribel; Bennasar Mar; Crispi Fatima; Borobio Virginia; Martinez Josep Maria; Gratacos Eduard; Borrell Antoni
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-4
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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This article is protected by copyright. All rights reserved.
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